@article {185,
	title = {A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy.},
	journal = {Epilepsia},
	volume = {48},
	year = {2007},
	month = {2007 Jul},
	pages = {1283-91},
	abstract = {PURPOSE: To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints.

METHODS: Twenty-three epilepsy patients with subjective memory difficulty were randomized to either 3 months of donepezil (10 mg/day) or 3 months of placebo treatment, and then crossed over to the other treatment arm. Patients and physicians were blinded to treatment phase throughout data acquisition. Assessment of memory and other cognitive functions, subjective memory, mood, and self-rated quality of life (QOL) and social functioning was performed at baseline and following completion of both treatment phases. Seizure frequency and severity as well as treatment emergent adverse effects were also monitored.

RESULTS: Donepezil treatment was not associated with improvement in memory or other cognitive functions, mood, social functioning or QOL. Comparable increases in self-rated memory functioning relative to baseline were evident during donepezil and placebo phases. Donepezil treatment was not associated with increased seizure frequency or severity. Similar to group results, analysis of change within individual patients as a function of treatment phase also showed neither significant benefit nor detriment associated with donepezil.

CONCLUSION: This study found no benefit on memory or other cognitive/psychological functions in a heterogeneous group of epilepsy patients with subjective memory difficulty. Further investigation would be required to determine whether individual patients, or those with particular epilepsy syndromes, might benefit from donepezil or other acetylcholinesterase inhibitors, or if a higher dosage might be effective.},
	keywords = {Cholinesterase Inhibitors, Cognition Disorders, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Epilepsy, Health Status, Humans, Indans, Memory Disorders, Neuropsychological Tests, Piperidines, Placebos, Quality of Life, Severity of Illness Index, Social Adjustment, Treatment Outcome},
	issn = {0013-9580},
	doi = {10.1111/j.1528-1167.2007.01114.x},
	author = {Hamberger, Marla J and Palmese, Christina A and Scarmeas, Nikolaos and Weintraub, David and Choi, Hyunmi and Hirsch, Lawrence J}
}
