@article {206,
	title = {IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury.},
	journal = {Neurology},
	volume = {65},
	year = {2005},
	month = {2005 Oct 11},
	pages = {1077-82},
	abstract = {OBJECTIVE: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI).

METHODS: Data from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95\% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant.

RESULTS: Compared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI (adjusted OR = 4.57; 95\% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant.

CONCLUSION: There is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage.},
	keywords = {Adult, Age Factors, Brain Edema, Brain Hemorrhage, Traumatic, DNA Mutational Analysis, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Testing, Genotype, Glasgow Coma Scale, Humans, Interleukin 1 Receptor Antagonist Protein, Interleukin-1, Male, Middle Aged, Minisatellite Repeats, Models, Neurological, Neurosurgical Procedures, Odds Ratio, Polymorphism, Genetic, Prospective Studies, Sex Factors, Sialoglycoproteins},
	issn = {1526-632X},
	doi = {10.1212/01.wnl.0000178890.93795.0e},
	author = {Hadjigeorgiou, G M and Paterakis, K and Dardiotis, E and Dardioti, M and Aggelakis, K and Tasiou, A and Xiromerisiou, G and Komnos, A and Zintzaras, E and Scarmeas, N. and Papadimitriou, A and Karantanas, A}
}
