@article {221,
	title = {Identification and differential vulnerability of a neural network in sleep deprivation.},
	journal = {Cereb Cortex},
	volume = {14},
	year = {2004},
	month = {2004 May},
	pages = {496-502},
	abstract = {The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation.},
	keywords = {Adaptation, Physiological, Adult, Brain Mapping, Cerebral Cortex, Cognition, Evoked Potentials, Visual, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Pattern Recognition, Automated, Psychomotor Performance, Sleep Deprivation, Task Performance and Analysis},
	issn = {1047-3211},
	doi = {10.1093/cercor/bhh011},
	author = {Bell-McGinty, Sandra and Habeck, Christian and Hilton, H John and Rakitin, Brian and Scarmeas, Nikolaos and Zarahn, Eric and Flynn, Joseph and DeLaPaz, Robert and Basner, Robert and Stern, Yaakov}
}
