@article {43596,
	title = {DABCO-Catalyzed Synthesis of Thiazolidine-2-thiones: System Development and Mechanistic Insights},
	journal = {Journal of Organic Chemistry},
	year = {2025},
	month = {2025},
	publisher = {American Chemical Society},
	abstract = {A base-catalyzed protocol is reported for the construction of 1,3-thiazolidine-2-thione scaffolds bearing quaternary carbon centers from carbon disulfide and α-tertiary propargylamines. The reaction proceeds using low catalyst loading, under ambient temperatures, and in the absence of solvent. Various α-tertiary propargylamines have been employed, affording a series of previously unreported thiazolidine-2-thione compounds and avoiding purification via column chromatography in certain cases. We also describe a one-pot strategy for the synthesis of the same products through a KA2 coupling-CS2 incorporation approach. The reaction mechanism and substituent-dependent catalytic behavior were studied through a combination of detailed experimental and computational studies.},
	author = {Chalkidis, Savvas G. and Hong, Sungil and Tsiadi, Anthi Markella and Fika, Evangelia and Tsoureas, Nikolaos and Mpourmpakis, Giannis and Georgios C. Vougioukalakis}
}
