@article {26979,
	title = {Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans},
	journal = {Curr Biol},
	volume = {25},
	number = {14},
	year = {2015},
	note = {Schiavi, AlfonsoMaglioni, SilviaPalikaras, KonstantinosShaik, AnjumaraStrappazzon, FlavieBrinkmann, VanessaTorgovnick, AlessandroCastelein, NataschaDe Henau, SashaBraeckman, Bart PCecconi, FrancescoTavernarakis, NektariosVentura, NatasciaengP40 OD010440/OD/NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tEnglandCurr Biol. 2015 Jul 20;25(14):1810-22. doi: 10.1016/j.cub.2015.05.059. Epub 2015 Jul 2.},
	month = {Jul 20},
	pages = {1810-22},
	edition = {2015/07/07},
	abstract = {Frataxin is a nuclear-encoded mitochondrial protein involved in the biogenesis of Fe-S-cluster-containing proteins and consequently in the functionality of the mitochondrial respiratory chain. Similar to other proteins that regulate mitochondrial respiration, severe frataxin deficiency leads to pathology in humans--Friedreich{\textquoteright}s ataxia, a life-threatening neurodegenerative disorder--and to developmental arrest in the nematode C. elegans. Interestingly, partial frataxin depletion extends C. elegans lifespan, and a similar anti-aging effect is prompted by reduced expression of other mitochondrial regulatory proteins from yeast to mammals. The beneficial adaptive responses to mild mitochondrial stress are still largely unknown and, if characterized, may suggest novel potential targets for the treatment of human mitochondria-associated, age-related disorders. Here we identify mitochondrial autophagy as an evolutionarily conserved response to frataxin silencing, and show for the first time that, similar to mammals, mitophagy is activated in C. elegans in response to mitochondrial stress in a pdr-1/Parkin-, pink-1/Pink-, and dct-1/Bnip3-dependent manner. The induction of mitophagy is part of a hypoxia-like, iron starvation response triggered upon frataxin depletion and causally involved in animal lifespan extension. We also identify non-overlapping hif-1 upstream (HIF-1-prolyl-hydroxylase) and downstream (globins) regulatory genes mediating lifespan extension upon frataxin and iron depletion. Our findings indicate that mitophagy induction is part of an adaptive iron starvation response induced as a protective mechanism against mitochondrial stress, thus suggesting novel potential therapeutic strategies for the treatment of mitochondrial-associated, age-related disorders.},
	keywords = {Anaerobiosis, Animals, Caenorhabditis elegans Proteins/genetics/metabolism, Caenorhabditis elegans/genetics/*physiology, Fasting, Iron-Binding Proteins, Iron/*deficiency, Longevity/drug effects, Mitophagy/*drug effects},
	isbn = {1879-0445 (Electronic)0960-9822 (Linking)},
	author = {Schiavi, A. and Maglioni, S. and Palikaras, K. and Shaik, A. and Strappazzon, F. and Brinkmann, V. and Torgovnick, A. and Castelein, N. and De Henau, S. and Braeckman, B. P. and Cecconi, F. and Tavernarakis, N. and Ventura, N.}
}
