@article {32246,
	title = {The crosstalk between microbiome and mitochondrial homeostasis in      neurodegeneration
},
	journal = {Cells},
	volume = {12},
	year = {2023},
	month = {2023},
	pages = {429},
	publisher = {MDPI AG},
	abstract = {Mitochondria are highly dynamic organelles that serve as the primary      cellular energy-generating system. Apart from ATP production, they are
      essential for many biological processes, including calcium homeostasis,
      lipid biogenesis, ROS regulation and programmed cell death, which
      collectively render them invaluable for neuronal integrity and function.
      Emerging evidence indicates that mitochondrial dysfunction and altered
      mitochondrial dynamics are crucial hallmarks of a wide variety of
      neurodevelopmental and neurodegenerative conditions. At the same time, the
      gut microbiome has been implicated in the pathogenesis of several
      neurodegenerative disorders due to the bidirectional communication between
      the gut and the central nervous system, known as the gut-brain axis. Here
      we summarize new insights into the complex interplay between mitochondria,
      gut microbiota and neurodegeneration, and we refer to animal models that
      could elucidate the underlying mechanisms, as well as novel interventions
      to tackle age-related neurodegenerative conditions, based on this
      intricate network.
},
	keywords = {Ageing, Alzheimer{\textquoteright}s disease, Amyotrophic Lateral Sclerosis, gut-brain axis, Huntington{\textquoteright}s disease, microbiome, Mitochondria, Neurodegeneration},
	isbn = {2073-4409},
	url = {http://dx.doi.org/10.3390/cells12030429https://www.ncbi.nlm.nih.gov/pubmed/36766772},
	author = {Fivos Borbolis and Mytilinaiou, Eirini and Palikaras, Konstantinos}
}
