<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nikoletopoulou, V.</style></author><author><style face="normal" font="default" size="100%">Markaki, M.</style></author><author><style face="normal" font="default" size="100%">Palikaras, K.</style></author><author><style face="normal" font="default" size="100%">Tavernarakis, N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Crosstalk between apoptosis, necrosis and autophagy</style></title><secondary-title><style face="normal" font="default" size="100%">Biochim Biophys Acta</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">*Autophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">*Signal Transduction</style></keyword><keyword><style  face="normal" font="default" size="100%">Adenosine Monophosphate activated Kinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Aif</style></keyword><keyword><style  face="normal" font="default" size="100%">Ampk</style></keyword><keyword><style  face="normal" font="default" size="100%">Apaf1</style></keyword><keyword><style  face="normal" font="default" size="100%">apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis Inducing Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptotic Protease Activating Factor 1</style></keyword><keyword><style  face="normal" font="default" size="100%">Autophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">B-cell lymphoma 2</style></keyword><keyword><style  face="normal" font="default" size="100%">B-cell lymphoma extra large</style></keyword><keyword><style  face="normal" font="default" size="100%">Bcl-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Bcl-2 homology</style></keyword><keyword><style  face="normal" font="default" size="100%">BCL-X(l)</style></keyword><keyword><style  face="normal" font="default" size="100%">Bec1</style></keyword><keyword><style  face="normal" font="default" size="100%">Beclin-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Bh</style></keyword><keyword><style  face="normal" font="default" size="100%">caspase 8</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell death</style></keyword><keyword><style  face="normal" font="default" size="100%">cellular inhibitor of apoptosis 1</style></keyword><keyword><style  face="normal" font="default" size="100%">cellular inhibitor of apoptosis 2</style></keyword><keyword><style  face="normal" font="default" size="100%">cIAP1</style></keyword><keyword><style  face="normal" font="default" size="100%">cIAP2</style></keyword><keyword><style  face="normal" font="default" size="100%">Damage-Regulated Autophagy Modulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Dapk</style></keyword><keyword><style  face="normal" font="default" size="100%">death associated protein kinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Dram</style></keyword><keyword><style  face="normal" font="default" size="100%">Fadd</style></keyword><keyword><style  face="normal" font="default" size="100%">FAS Associated Death Domain</style></keyword><keyword><style  face="normal" font="default" size="100%">Flice</style></keyword><keyword><style  face="normal" font="default" size="100%">FLICE-Like Inhibitory Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Flip</style></keyword><keyword><style  face="normal" font="default" size="100%">Forkhead Box Protein O1</style></keyword><keyword><style  face="normal" font="default" size="100%">Foxo1</style></keyword><keyword><style  face="normal" font="default" size="100%">Hdgf</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoma Derived Growth Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">High Mobility Group protein B1</style></keyword><keyword><style  face="normal" font="default" size="100%">Hmgb1</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Igf1</style></keyword><keyword><style  face="normal" font="default" size="100%">IL1beta</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin Growth Factor 1</style></keyword><keyword><style  face="normal" font="default" size="100%">interleukin 1beta</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver Kinase B1</style></keyword><keyword><style  face="normal" font="default" size="100%">Lkb1</style></keyword><keyword><style  face="normal" font="default" size="100%">mammalian target of rapamycin</style></keyword><keyword><style  face="normal" font="default" size="100%">MEFs</style></keyword><keyword><style  face="normal" font="default" size="100%">mitochondrial outer membrane permeabilization</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Mnng</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Biological</style></keyword><keyword><style  face="normal" font="default" size="100%">Momp</style></keyword><keyword><style  face="normal" font="default" size="100%">mouse embryonic fibroblasts</style></keyword><keyword><style  face="normal" font="default" size="100%">mTOR</style></keyword><keyword><style  face="normal" font="default" size="100%">N-methyl-N0-nitrosoguanidine</style></keyword><keyword><style  face="normal" font="default" size="100%">Necroptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis/*pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Nemo</style></keyword><keyword><style  face="normal" font="default" size="100%">NF-kB</style></keyword><keyword><style  face="normal" font="default" size="100%">NF-kB essential modulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Nlrp3</style></keyword><keyword><style  face="normal" font="default" size="100%">NOD-like receptor family pyrin domain containing 3</style></keyword><keyword><style  face="normal" font="default" size="100%">Nuclear factor kappa-light-chain-enhancer of activated B cells</style></keyword><keyword><style  face="normal" font="default" size="100%">p53-Upregulated Modulator of Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Pamp</style></keyword><keyword><style  face="normal" font="default" size="100%">Parp1</style></keyword><keyword><style  face="normal" font="default" size="100%">Pathogen Associated Molecular Patterns</style></keyword><keyword><style  face="normal" font="default" size="100%">pathogen recognition receptor</style></keyword><keyword><style  face="normal" font="default" size="100%">Pcd</style></keyword><keyword><style  face="normal" font="default" size="100%">permeability transition pore</style></keyword><keyword><style  face="normal" font="default" size="100%">Phosphatidyl Inositol 3 Kinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Pi3k</style></keyword><keyword><style  face="normal" font="default" size="100%">Poly(ADP ribose) Polymerase 1</style></keyword><keyword><style  face="normal" font="default" size="100%">programmed cell death</style></keyword><keyword><style  face="normal" font="default" size="100%">Prr</style></keyword><keyword><style  face="normal" font="default" size="100%">Ptp</style></keyword><keyword><style  face="normal" font="default" size="100%">Puma</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor Interacting Protein 1</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor Interacting Protein 3</style></keyword><keyword><style  face="normal" font="default" size="100%">Rip1</style></keyword><keyword><style  face="normal" font="default" size="100%">Rip3</style></keyword><keyword><style  face="normal" font="default" size="100%">Sirt2</style></keyword><keyword><style  face="normal" font="default" size="100%">Sirtuin 2</style></keyword><keyword><style  face="normal" font="default" size="100%">tAIF</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF related apoptosis inducing ligand</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFalpha</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFalpha Receptor 1</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFalpha receptor 2</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFR Associated Death Domain</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFR Associated Factor 2</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFR Associated Factor 5</style></keyword><keyword><style  face="normal" font="default" size="100%">Tnfr1</style></keyword><keyword><style  face="normal" font="default" size="100%">Tnfr2</style></keyword><keyword><style  face="normal" font="default" size="100%">Tradd</style></keyword><keyword><style  face="normal" font="default" size="100%">Traf2</style></keyword><keyword><style  face="normal" font="default" size="100%">Traf5</style></keyword><keyword><style  face="normal" font="default" size="100%">Trail</style></keyword><keyword><style  face="normal" font="default" size="100%">TRAIL Receptor 1</style></keyword><keyword><style  face="normal" font="default" size="100%">TRAIL Receptor 2</style></keyword><keyword><style  face="normal" font="default" size="100%">Trailr1</style></keyword><keyword><style  face="normal" font="default" size="100%">Trailr2</style></keyword><keyword><style  face="normal" font="default" size="100%">truncated Apoptosis Inducing Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor Necrosis Factor alpha</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Dec</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">12</style></number><edition><style face="normal" font="default" size="100%">2013/06/19</style></edition><volume><style face="normal" font="default" size="100%">1833</style></volume><pages><style face="normal" font="default" size="100%">3448-3459</style></pages><isbn><style face="normal" font="default" size="100%">0006-3002 (Print)0006-3002 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Apoptosis and necrosis are the two major modes of cell death, the molecular mechanisms of which have been extensively studied. Although initially thought to constitute mutually exclusive cellular states, recent findings reveal cellular contexts that require a balanced interplay between these two modes of cellular demise. Several death initiator and effector molecules, signaling pathways and subcellular sites have been identified as key mediators in both processes, either by constituting common modules or alternatively by functioning as a switch allowing cells to decide which route to take, depending on the specific situation. Importantly, autophagy, which is a predominantly cytoprotective process, has been linked to both types of cell death, serving either a pro-survival or pro-death function. Here we review the recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy, focusing on the relevance and impact of this crosstalk in normal development and in pathology. This article is part of a Special Section entitled: Cell Death Pathways.</style></abstract><accession-num><style face="normal" font="default" size="100%">23770045</style></accession-num><notes><style face="normal" font="default" size="100%">Nikoletopoulou, VassilikiMarkaki, MariaPalikaras, KonstantinosTavernarakis, NektariosengResearch Support, Non-U.S. Gov'tReviewNetherlandsBiochim Biophys Acta. 2013 Dec;1833(12):3448-3459. doi: 10.1016/j.bbamcr.2013.06.001. Epub 2013 Jun 13.</style></notes><auth-address><style face="normal" font="default" size="100%">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece. Electronic address: tavernarakis@imbb.forth.gr.</style></auth-address></record></records></xml>