<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Palikaras, K.</style></author><author><style face="normal" font="default" size="100%">Tavernarakis, N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis</style></title><secondary-title><style face="normal" font="default" size="100%">Exp Gerontol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Energy Metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">*Mitochondrial Turnover</style></keyword><keyword><style  face="normal" font="default" size="100%">*Mitophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Ageing</style></keyword><keyword><style  face="normal" font="default" size="100%">Aging/metabolism/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Animals</style></keyword><keyword><style  face="normal" font="default" size="100%">Autophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">homeostasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitochondria</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitochondria/*metabolism/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitochondrial Proteins/metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">mitophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">parkin</style></keyword><keyword><style  face="normal" font="default" size="100%">PGC-1alpha</style></keyword><keyword><style  face="normal" font="default" size="100%">Pink1</style></keyword><keyword><style  face="normal" font="default" size="100%">signal transduction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Aug</style></date></pub-dates></dates><edition><style face="normal" font="default" size="100%">2014/02/04</style></edition><volume><style face="normal" font="default" size="100%">56</style></volume><pages><style face="normal" font="default" size="100%">182-8</style></pages><isbn><style face="normal" font="default" size="100%">1873-6815 (Electronic)0531-5565 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Mitochondria are highly dynamic organelles and their proper function is crucial for the maintenance of cellular homeostasis. Mitochondrial biogenesis and mitophagy are two pathways that regulate mitochondrial content and metabolism preserving homeostasis. The tight regulation between these opposing processes is essential for cellular adaptation in response to cellular metabolic state, stress and other intracellular or environmental signals. Interestingly, imbalance between mitochondrial proliferation and degradation process results in progressive development of numerous pathologic conditions. Here we review recent studies that highlight the intricate interplay between mitochondrial biogenesis and mitophagy, mainly focusing on the molecular mechanisms that govern the coordination of these processes and their involvement in age-related pathologies and ageing.</style></abstract><accession-num><style face="normal" font="default" size="100%">24486129</style></accession-num><notes><style face="normal" font="default" size="100%">Palikaras, KonstantinosTavernarakis, NektariosengResearch Support, Non-U.S. Gov'tReviewEnglandExp Gerontol. 2014 Aug;56:182-8. doi: 10.1016/j.exger.2014.01.021. Epub 2014 Jan 28.</style></notes><auth-address><style face="normal" font="default" size="100%">Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece.Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 71110, Crete, Greece. Electronic address: tavernarakis@imbb.forth.gr.</style></auth-address></record></records></xml>