<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Doxaki, C.</style></author><author><style face="normal" font="default" size="100%">Palikaras, K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuronal Mitophagy: Friend or Foe?</style></title><secondary-title><style face="normal" font="default" size="100%">Front Cell Dev Biol</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell death</style></keyword><keyword><style  face="normal" font="default" size="100%">commercial or financial relationships that could be construed as a potential</style></keyword><keyword><style  face="normal" font="default" size="100%">conflict of interest.</style></keyword><keyword><style  face="normal" font="default" size="100%">Energy Metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">homeostasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitochondria</style></keyword><keyword><style  face="normal" font="default" size="100%">mitophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurodegeneration</style></keyword><keyword><style  face="normal" font="default" size="100%">neuroprotection</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year></dates><edition><style face="normal" font="default" size="100%">2021/02/05</style></edition><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">611938</style></pages><isbn><style face="normal" font="default" size="100%">2296-634X (Print)2296-634X (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Maintenance of neuronal homeostasis is a challenging task, due to unique cellular organization and bioenergetic demands of post-mitotic neurons. It is increasingly appreciated that impairment of mitochondrial homeostasis represents an early sign of neuronal dysfunction that is common in both age-related neurodegenerative as well as in neurodevelopmental disorders. Mitochondrial selective autophagy, known as mitophagy, regulates mitochondrial number ensuring cellular adaptation in response to several intracellular and environmental stimuli. Mounting evidence underlines that deregulation of mitophagy levels has an instructive role in the process of neurodegeneration. Although mitophagy induction mediates the elimination of damaged mitochondria and confers neuroprotection, uncontrolled runaway mitophagy could reduce mitochondrial content overstressing the remaining organelles and eventually triggering neuronal cell death. Unveiling the molecular mechanisms of neuronal mitophagy and its intricate role in neuronal survival and cell death, will assist in the development of novel mitophagy modulators to promote cellular and organismal homeostasis in health and disease.</style></abstract><accession-num><style face="normal" font="default" size="100%">33537304</style></accession-num><notes><style face="normal" font="default" size="100%">Doxaki, ChristinaPalikaras, KonstantinosengReviewSwitzerlandFront Cell Dev Biol. 2021 Jan 18;8:611938. doi: 10.3389/fcell.2020.611938. eCollection 2020.</style></notes><custom2><style face="normal" font="default" size="100%">PMC7848077</style></custom2><auth-address><style face="normal" font="default" size="100%">General University Hospital of Heraklion, Crete, Greece.Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Crete, Greece.</style></auth-address></record></records></xml>