<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aman, Y</style></author><author><style face="normal" font="default" size="100%">Schmauck-Medina, T</style></author><author><style face="normal" font="default" size="100%">Hansen, M</style></author><author><style face="normal" font="default" size="100%">Morimoto, RI</style></author><author><style face="normal" font="default" size="100%">Simon, A. K.</style></author><author><style face="normal" font="default" size="100%">Bjedov, I</style></author><author><style face="normal" font="default" size="100%">Palikaras, K.</style></author><author><style face="normal" font="default" size="100%">Simonsen, A</style></author><author><style face="normal" font="default" size="100%">Johansen, T</style></author><author><style face="normal" font="default" size="100%">Tavernarakis, N.</style></author><author><style face="normal" font="default" size="100%">Rubinsztein, D. C.</style></author><author><style face="normal" font="default" size="100%">Partridge, L</style></author><author><style face="normal" font="default" size="100%">Kroemer, G.</style></author><author><style face="normal" font="default" size="100%">Labbadia, J</style></author><author><style face="normal" font="default" size="100%">Fang, E. F.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Autophagy in healthy aging and disease</style></title><secondary-title><style face="normal" font="default" size="100%">Nat Aging</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Aug</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><edition><style face="normal" font="default" size="100%">2021/12/14</style></edition><volume><style face="normal" font="default" size="100%">1</style></volume><pages><style face="normal" font="default" size="100%">634-650</style></pages><isbn><style face="normal" font="default" size="100%">2662-8465 (Electronic)2662-8465 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.</style></abstract><accession-num><style face="normal" font="default" size="100%">34901876</style></accession-num><notes><style face="normal" font="default" size="100%">Aman, YahyahSchmauck-Medina, TomasHansen, MaleneMorimoto, Richard ISimon, Anna KatharinaBjedov, IvanaPalikaras, KonstantinosSimonsen, AnneJohansen, TerjeTavernarakis, NektariosRubinsztein, David CPartridge, LindaKroemer, GuidoLabbadia, JohnFang, Evandro FengR01 AG038664/AG/NIA NIH HHS/R01 GM117466/GM/NIGMS NIH HHS/R37 AG026647/AG/NIA NIH HHS/RF1 AG057296/AG/NIA NIH HHS/Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12.</style></notes><custom2><style face="normal" font="default" size="100%">PMC8659158</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lorenskog, Norway.Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK.These authors contributed equally: Yahyah Aman, Tomas Schmauck-Medina.Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL, USA.Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.UCL Cancer Institute, University College London, London, UK.Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.Department of Molecular Medicine, Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, The University of Oslo, Oslo, Norway.Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Oslo, Norway.Molecular Cancer Research Group, Institute of Medical Biology, University of Tromso-The Arctic University of Norway, Tromso, Norway.Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Greece.Department of Basic Sciences, School of Medicine, University of Crete, Heraklion, Greece.Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK.UK Dementia Research Institute, University of Cambridge, Cambridge, UK.Department of Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.Centre de Recherche des Cordeliers, Equipe Labellisee par la Ligue contre le Cancer, Universite de Paris, Sorbonne Universite, INSERM U1138, Institut Universitaire de France, Paris, France.Metabolomics and Cell Biology Platforms, Gustave Roussy, Villejuif, France.Pole de Biologie, Hopital Europeen Georges Pompidou, AP-HP, Paris, France.Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.</style></auth-address></record></records></xml>