@article {44011,
	title = {Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.},
	journal = {J Clin Oncol},
	volume = {39},
	year = {2021},
	month = {2021 Jan 01},
	pages = {66-78},
	abstract = {PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway.

PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation).

RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2\%  4.9\%; adjusted odds ratio [aOR], 0.62; 95\% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1\%  3.6\%; aOR, 0.53; 95\% CI, 0.36 to 0.76).

CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.},
	keywords = {Aged, Aged, 80 and over, Cohort Studies, Covid-19, Critical Care, Elective Surgical Procedures, Epidemics, Female, Humans, International Cooperation, Logistic Models, Male, Middle Aged, Neoplasms, Outcome Assessment, Health Care, Postoperative Complications, SARS-CoV-2},
	issn = {1527-7755},
	doi = {10.1200/JCO.20.01933},
	author = {Glasbey, James C and Nepogodiev, Dmitri and Simoes, Joana F F and Omar, Omar and Li, Elizabeth and Venn, Mary L and Venn, Mary L and Abou Chaar, Mohammad K and Capizzi, Vita and Chaudhry, Daoud and Desai, Anant and Edwards, Jonathan G and Evans, Jonathan P and Fiore, Marco and Videria, Jose Flavio and Ford, Samuel J and Ganly, Ian and Griffiths, Ewen A and Gujjuri, Rohan R and Kolias, Angelos G and Kaafarani, Haytham M A and Minaya-Bravo, Ana and McKay, Siobhan C and Mohan, Helen M and Roberts, Keith J and San Miguel-M{\'e}ndez, Carlos and Pockney, Peter and Shaw, Richard and Smart, Neil J and Stewart, Grant D and Sundar Mrcog, Sudha and Vidya, Raghavan and Bhangu, Aneel A}
}
