@article {44018,
	title = {Granisetron versus tropisetron in the prevention of postoperative nausea and vomiting after total thyroidectomy.},
	journal = {Saudi J Anaesth},
	volume = {7},
	year = {2013},
	month = {2013 Jan},
	pages = {68-74},
	abstract = {BACKGROUND: Postoperative nausea and vomiting (PONV) are frequently encountered after thyroidectomy. For PONV prevention, selective serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are considered one of the first-line therapy. We report on the efficiency of granisetron and tropisetron, with that of placebo on the prevention of PONV in patients undergoing total thyroidectomy.

METHODS: One hundred twenty-seven patients were divided into three groups and randomized to receive intravenously, prior to induction of anesthesia, tropisetron 5 mg, or granisetron 3 mg, or normal saline. All patients received additionally 0.625 mg droperidol. All episodes of postoperative PONV during the first 24 h after surgery were evaluated.

RESULTS: Nausea visual analogue scale (VAS) score was lower in tropisetron and granisetron groups than the control group at all measurements (P<0.01) except for the 8-h measurement for tropisetron (P=0.075). Moreover, granisetron performed better than tropisetron (P<0.011 at 4 h and P<0.01 at all other points of time) apart from the 2-h measurement. Vomiting occurred in 22.2\%, 27.5\%, and 37.5\% in granisetron, tropisetron, and control groups, respectively (P=0.43).

CONCLUSIONS: The combination of the 5-HT3 antagonists with droperidol given before induction of anesthesia is well tolerated and superior to droperidol alone in preventing nausea but not vomiting after total thyroidectomy.},
	issn = {1658-354X},
	doi = {10.4103/1658-354X.109817},
	author = {Papadima, Artemisia and Gourgiotis, Stavros and Lagoudianakis, Emmanuel and Pappas, Apostolos and Seretis, Charalampos and Antonakis, Pantelis T and Markogiannakis, Haridimos and Makri, Ira and Manouras, Andreas}
}
