@article {44035,
	title = {Parecoxib vs. lornoxicam in the treatment of postoperative pain after laparoscopic cholecystectomy: a prospective randomized placebo-controlled trial.},
	journal = {Eur J Anaesthesiol},
	volume = {24},
	year = {2007},
	month = {2007 Feb},
	pages = {154-8},
	abstract = {BACKGROUND AND OBJECTIVE: Non-steroidal anti-inflammatory drugs are considered as an effective treatment of postoperative pain after laparoscopic cholecystectomy. COX-2 inhibitors are newer drugs having less adverse effects. Data supporting their efficacy postoperatively in comparison to older non-steroidal anti-inflammatory drugs are scarce. Our study is a prospective, randomized, double-blinded, placebo-controlled trial comparing the efficacy of lornoxicam vs. parecoxib for the management of pain after laparoscopic cholecystectomy.

MATERIALS AND METHODS: We enrolled 76 patients, ASA I and II, scheduled for elective laparoscopic cholecystectomy. The patients were randomized to receive before induction parecoxib 40 mg i.v., lornoxicam 8 mg i.v. or placebo. Pain at rest and on movement was assessed using a visual analogue scale at 0, 6, 12 h postoperatively. Total meperidine consumption and adverse effects were also recorded.

RESULTS: At 12 h, visual analogue scale scores at rest and on movement were significantly lower with parecoxib and lornoxicam compared with control ( P = 0.047). The percentage of patients needing meperidine and the average dose of meperidine administered was significantly lower with parecoxib and lornoxicam compared with control (P < 0.001 and P = 0.018). There was no difference between parecoxib and lornoxicam. One patient receiving lornoxicam vomited.

CONCLUSIONS: Parecoxib 40 mg i.v. and lornoxicam 8 mg i.v. were equianalgesic and both were more efficacious than placebo for the management of pain after laparoscopic cholecystectomy.},
	keywords = {Analgesics, Opioid, Anti-Inflammatory Agents, Non-Steroidal, Cholecystectomy, Laparoscopic, Cyclooxygenase Inhibitors, Elective Surgical Procedures, Female, Humans, Isoxazoles, Male, Meperidine, Middle Aged, Pain Measurement, Pain, Postoperative, Piroxicam, Placebos, Prospective Studies, Time Factors, Treatment Outcome},
	issn = {0265-0215},
	doi = {10.1017/S0265021506001293},
	author = {Papadima, A and Lagoudianakis, E E and Antonakis, P T and Pattas, M and Kremastinou, F and Katergiannakis, V and Manouras, A and Georgiou, L}
}
