@article {44041,
	title = {Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats.},
	journal = {World J Gastroenterol},
	volume = {11},
	year = {2005},
	month = {2005 May 14},
	pages = {2733-8},
	abstract = {AIM: To develop an experimental model of islet allotransplantation in diabetic rats and to determine the positive or adverse effects of MMF as a single agent.

METHODS: Thirty-six male Wistar rats and 18 male Lewis rats were used as recipients and donors respectively. Diabetes was induced by the use of streptozotocin (60 mg/kg) intraperitoneally. Unpurified islets were isolated using the collagenase digestion technique and transplanted into the splenic parenchyma. The recipients were randomly assigned to one of the following three groups: group A (control group) had no immunosuppression; group B received cyclosporine (CsA) (5 mg/kg); group C received mycophenolate mofetil (MMF) (20 mg/kg). The animals were killed on the 12th d. Blood and grafted tissues were obtained for laboratory and histological assessment.

RESULTS: Median allograft survival was significantly higher in the two therapy groups than that in the controls (10 and 12 d for CsA and MMF respectively vs 0 d for the control group, P<0.01). No difference in allograft survival between the CsA and MMF groups was found. However, MMF had less renal and hepatic toxicity and allowed weight gain.

CONCLUSION: Monotherapy with MMF for immunosuppression was safe in an experimental model of islet allotransplantation and was equally effective with cyclosporine, with less toxicity.},
	keywords = {Animals, Cyclosporine, Diabetes Mellitus, Experimental, Graft Survival, Immunosuppressive Agents, Islets of Langerhans, Islets of Langerhans Transplantation, Male, Mycophenolic Acid, Rats, Rats, Wistar},
	issn = {1007-9327},
	doi = {10.3748/wjg.v11.i18.2733},
	author = {Fotiadis, Constantin and Xekouki, Paraskevi and Papalois, Apostolos E and Antonakis, Pantelis T and Sfiniadakis, Ioannis and Flogeras, Dimitrios and Karampela, Eleutheria and Zografos, George}
}
