@article {18087,
	title = {Motion synchronisation patterns of the carotid atheromatous plaque from B-mode ultrasound},
	journal = {Sci Rep},
	volume = {10},
	year = {2020},
	abstract = {Asynchronous movement of the carotid atheromatous plaque from B-mode ultrasound has been previously reported, and associated with higher risk of stroke, but not quantitatively estimated. Based on the hypothesis that asynchronous plaque motion is associated with vulnerable plaque, in this study, synchronisation patterns of different tissue areas were estimated using cross-correlations of displacement waveforms. In 135 plaques (77 subjects), plaque radial deformation was synchronised by approximately 50\% with the arterial diameter, and the mean phase shift was 0.4 s. Within the plaque, the mean phase shifts between the displacements of the top and bottom surfaces were 0.2 s and 0.3 s, in the radial and longitudinal directions, respectively, and the synchronisation about 80\% in both directions. Classification of phase-shift-based features using Random Forests yielded Area-Under-the-Curve scores of 0.81, 0.79, 0.89 and 0.90 for echogenicity, symptomaticity, stenosis degree and plaque risk, respectively. Statistical analysis showed that echolucent, high-stenosis and high-risk plaques exhibited higher phase shifts between the radial displacements of their top and bottom surfaces. These findings are useful in the study of plaque kinematics.},
	url = {https://www.nature.com/articles/s41598-020-65340-2},
	author = {Spyretta Golemati and Eleni Patelaki and Aimilia Gastounioti and Ioannis Andreadis and Christos D. Liapis and Konstantina S. Nikita}
}
