@article {576,
	title = {Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters.},
	journal = {Eur J Endocrinol},
	volume = {167},
	year = {2012},
	month = {2012 Sep},
	pages = {433-40},
	abstract = {{OBJECTIVE: α-Klotho (α-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling. The role of α-KL in neonates, known to be prone to metabolic disturbances and oxidative stress, is not known. The aim of this study was to evaluate circulating soluble α-KL concentrations in preterm and full-term neonates and unravel possible correlations with growth, metabolism, and indices of oxidative stress. DESIGN: Prospective study. METHODS: Plasma-soluble α-KL levels were determined by specific ELISA in 50 healthy neonates (25 preterm, mean (s.d.) gestational age (GA) 33.7 (1.1) weeks, and 25 full-term infants) at days 14 and 28 of life. Associations of α-KL with anthropometric, metabolic parameters, and indices of oxidative stress were examined. RESULTS: α-KL levels were significantly higher in full-term than in preterm infants at both days 14 (1099 (480) pg/ml vs 884 (239) pg/ml respectively; P<0.05) and 28 (1277 (444) pg/ml vs 983 (264) pg/ml respectively; P<0.01). In both preterm and full-term infants, α-KL levels increased significantly from day 14 to 28 of life (P<0.001). Circulating α-KL concentrations correlated with GA (β=0.32},
	keywords = {Age Factors, Biological Markers, Child Development, Energy Metabolism, Female, Glucuronidase, Humans, Infant, Male, Newborn, Oxidative Stress, Premature},
	issn = {1479-683X},
	doi = {10.1530/EJE-12-0476},
	author = {Tania Siahanidou and Garatzioti, Maria and Lazaropoulou, Christina and Kourlaba, Georgia and Papassotiriou, Ioannis and Kino, Tomoshige and Imura, Akihiro and Nabeshima, Yo-ichi and Chrousos, George}
}
