@article {590,
	title = {Peptide YY (3-36) represents a high percentage of total PYY immunoreactivity in preterm and full-term infants and correlates independently with markers of adiposity and serum ghrelin concentrations.},
	journal = {Pediatr Res},
	volume = {62},
	year = {2007},
	month = {2007 Aug},
	pages = {200-3},
	abstract = {The gut hormone peptide YY 3-36 [PYY (3-36)] has been suggested to posses anorexigenic actions in animals and human adults. However, its circulating concentrations and function have not been studied in neonates. Serum concentrations of PYY (3-36) were determined by RIA (RIA) in 62 healthy preterm infants [mean(SD) gestational age, 32.0(2.1) weeks; postnatal age, 40.9(14.8 d)] and 15 healthy fullterm infants of comparable postnatal age and gender. The correlations between PYY (3-36) levels and anthropometric characteristics, food intake, growth rates and circulating concentrations of total PYY, ghrelin, leptin, insulin and adiponectin were examined. Mean (SD) PYY (3-36) concentrations were higher in preterm [543.7(157.6) ng/L) than full term infants [350.9(114.1) ng/L; p < 0.001) and accounted for 48\% and 42\% of total PYY basal plasma immunoreactivity in preterm and full term infants, respectively. In multiple regression analysis, PYY (3-36) concentrations correlated negatively with the infants{\textquoteright} BMI and positively with serum ghrelin concentrations, but not with caloric intake, weight gain or concentrations of any other hormone studied. In conclusion, PYY (3-36) represents almost half of total PYY immunoreactivity in neonates. It{\textquoteright}s correlations with ghrelin and BMI suggest a role of this peptide in the regulation of energy homeostasis; however, its specific functions and physiologic significance in neonates remain to be elucidated.},
	keywords = {Adiponectin, Adiposity, Body Mass Index, Energy Intake, Energy Metabolism, Female, Gestational Age, Ghrelin, homeostasis, Humans, Infant, Insulin, Leptin, Male, Newborn, Peptide Fragments, Peptide Hormones, Peptide YY, Premature, Radioimmunoassay, Weight Gain},
	issn = {0031-3998},
	doi = {10.1203/PDR.0b013e3180a76dad},
	author = {Tania Siahanidou and Mandyla, Helen and Militsi, Helen and Papassotiriou, Ioannis and Chrousos, George}
}
