@article {9764, title = {Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2}, journal = {Journal of Peptide Science}, volume = {14}, number = {10}, year = {2008}, month = {Oct}, pages = {1111-1120}, abstract = {A variety of lipophilic 2-oxoamides containing sulfonamide analogs of γ-amino acids as well as acyl sulfonamides of γ-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA2\ and GVIA iPLA2\ as well as secreted GV sPLA2\ was evaluated. The sulfonamide group seems a bioisosteric group suitable to replace the carboxyl group in 2-oxoamide inhibitors of GVIA cPLA2.}, keywords = {2-Oxoamides, acyl sulfonamides, aldol reactions, arachidonic-acid, Cells, group-iia, group-iva, group-v, Inhibitors, one-pot conversion, phospholipase a(2), release, sulfonamides, superfamily}, isbn = {1075-2617}, author = {Antonopoulou, G. and Magrioti, V. and Stephens, D. and Constantinou-Kokotou, V. and Dennis, E. A. and Kokotos, G.} }