@article {9770, title = {Synthesis of enantiopure non-natural α-amino acids using tert-butyl (2S)-2-[bis- (tert-butoxycarbonyl)amino]5-oxopentanoate as key-intermediate: The first synthesis of (S)-2-amino-oleic acid}, journal = {Journal of Peptide Research}, volume = {58}, number = {4}, year = {2001}, note = {Cited By :11Export Date: 18 January 2017}, pages = {325-331}, type = {Article}, abstract = {A general method for the synthesis of enantiopure non-natural α-amino acids is described. The key intermediate\ tert-butyl (2S)-2-[bis(tert-butoxycarbonyl)amino]-5-oxopentanoate was obtained from\ l-glutamic acid after suitable protection and selective reduction of the γ-methyl ester group by DIBALH. Wittig reaction of this chiral aldehyde with various ylides led to a variety of δ,ε-unsaturated α-amino acids. This methodology was applied to the synthesis of (S)-2-amino-oleic acid.}, author = {Constantinou-Kokotou, V. and Magrioti, V. and Markidis, T. and Kokotos, G.} }