@article {9771,
	title = {Sterically Hindered Triacylglycerol Analogues as Potent Inhibitors of Human Digestive Lipases},
	journal = {Chemistry - A European Journal},
	volume = {10},
	number = {5},
	year = {2004},
	pages = {1133-1140},
	publisher = {WILEY-VCH Verlag},
	abstract = {<span>A novel class of inhibitors of human digestive lipases have been developed. Various sterically hindered triacylglycerols based on 2-methyl- and 2-butylglycerol, and/or 2-methyl fatty acids were synthesized. The triacylglycerol analogues were tested for their ability to form stable monomolecular films at the air/water interface by recording their surface-pressure/molecular-area compression isotherms. The inhibition of human pancreatic and gastric lipases by the sterically hindered triacylglycerol analogues was studied by using the monolayer technique with mixed films of 1,2-dicaprin, which contained variable proportions of each inhibitor. Triolein analogues that contain a butyl group at the 2-position of the glycerol backbone or methyl groups both at the 2-position of glycerol, and the α-position of each oleic acid residue were potent inhibitors; this caused a 50 \% decrease in HPL activity at 0.003 molar fraction.</span>},
	keywords = {Enzyme Inhibitors, enzymes, Lipids, monolayers, triacylglycerol analogues},
	isbn = {1521-3765},
	author = {Constantinou-Kokotou, Violetta and Magrioti, Victoria and Verger, Robert}
}
