@article {9782, title = {Synthesis and in vivo anti-inflammatory activity of long-chain 2-amino-alcohols}, journal = {Bioorganic and Medicinal Chemistry Letters}, volume = {13}, number = {3}, year = {2003}, note = {Cited By :10Export Date: 18 January 2017}, pages = {375-377}, type = {Article}, abstract = {

The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glycerol was carried out starting from\ l- or\ d-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED50\ from 0.017 to 0.010 mmol/kg).\ The synthesis, anti-inflammatory and analgesic activity of long-chain 2-amino-alcohols is reported.

}, author = {Magrioti, V. and Hadjipavlou-Litina, D. and Constantinou-Kokotou, V.} }