@article {9786, title = {A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity}, journal = {Bioorganic and Medicinal Chemistry Letters}, volume = {18}, number = {20}, year = {2008}, note = {Cited By :7Export Date: 18 January 2017}, pages = {5424-5427}, type = {Article}, abstract = {A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (Ki\ 21.8\ μM) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.}, author = {Magrioti, V. and Naxakis, G. and Hadjipavlou-Litina, D. and Makriyannis, A. and Kokotos, G.} }