@article {9788, title = {Triacylglycerols Based on 2-(N-tert-Butoxycarbonylamino)oleic Acid Are Potent Inhibitors of Pancreatic Lipase}, journal = {Journal of Medicinal Chemistry}, volume = {47}, number = {2}, year = {2004}, note = {Cited By :12Export Date: 18 January 2017}, pages = {288-291}, type = {Article}, abstract = {A novel class of potent human pancreatic lipase (HPL) inhibitors was developed. Triacylglycerol analogues containing 2-(N-tert-butoxycarbonylamino) fatty acids were synthesized, and their ability to form stable films at the air/water interface was studied. The inhibition of human digestive lipases by the compounds synthesized was studied by the monolayer technique, and the triesters of glycerol and 2-methylglycerol with 2-(N-tert-butoxycarbonylamino)oleic acid were found to be potent inhibitors of HPL.}, author = {Magrioti, V. and Verger, R. and Constantinou-Kokotou, V.} }