@article {9793, title = {Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells}, journal = {Bioorganic and Medicinal Chemistry}, volume = {24}, number = {13}, year = {2016}, note = {Export Date: 18 January 2017}, pages = {3029-3034}, type = {Article}, abstract = {The upregulation of PGE2\ by mesangial cells has been observed under chronic inflammation condition. In the present work, renal mesangial cells were stimulated to trigger a huge increase of PGE2\ synthesis and were treated in the absence or presence of known PLA2\ inhibitors. A variety of synthetic inhibitors, mainly developed in our labs, which are known to selectively inhibit each of GIVA cPLA2, GVIA iPLA2, and GIIA/GV sPLA2, were used as tools in this study. Synthetic sPLA2\ inhibitors, such as GK115 (an amide derivative based on the non-natural amino acid (R)-γ-norleucine) as well as GK126 and GK241 (2-oxoamides based on the natural (S)-α-amino acid leucine and valine, respectively) presented an interesting effect on the suppression of PGE2\ formation.}, author = {Vasilakaki, S. and Barbayianni, E. and Magrioti, V. and Pastukhov, O. and Constantinou-Kokotou, V. and Huwiler, A. and Kokotos, G.} }