<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Antonopoulou, G.</style></author><author><style face="normal" font="default" size="100%">Barbayianni, E.</style></author><author><style face="normal" font="default" size="100%">Magrioti, V.</style></author><author><style face="normal" font="default" size="100%">Cotton, N.</style></author><author><style face="normal" font="default" size="100%">Stephens, D.</style></author><author><style face="normal" font="default" size="100%">Constantinou-Kokotou, V.</style></author><author><style face="normal" font="default" size="100%">Dennis, E. A.</style></author><author><style face="normal" font="default" size="100%">Kokotos, G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A&lt;sub&gt;2&lt;/sub&gt; enzymes</style></title><secondary-title><style face="normal" font="default" size="100%">Bioorganic and Medicinal Chemistry</style></secondary-title><short-title><style face="normal" font="default" size="100%">Bioorg Med Chem</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2-Oxoamides</style></keyword><keyword><style  face="normal" font="default" size="100%">Amides</style></keyword><keyword><style  face="normal" font="default" size="100%">Amino acids</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Phospholipase A&lt;sub&gt;2&lt;/sub&gt;</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year></dates><number><style face="normal" font="default" size="100%">24</style></number><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">10257-10269</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;span&gt;A variety of 2-oxoamides and related amides based on natural and non-natural amino acids were synthesized. Their activity on two human intracellular phospholipases (GIVA cPLA&lt;/span&gt;&lt;sub&gt;&lt;span&gt;2&lt;/span&gt;&lt;/sub&gt;&lt;span&gt;&amp;nbsp;and GVIA iPLA&lt;/span&gt;&lt;sub&gt;&lt;span&gt;2&lt;/span&gt;&lt;/sub&gt;&lt;span&gt;) and one human secretory phospholipase (GV sPLA&lt;/span&gt;&lt;sub&gt;&lt;span&gt;2&lt;/span&gt;&lt;/sub&gt;&lt;span&gt;) was evaluated. We show that an amide based on (&lt;/span&gt;&lt;em&gt;R&lt;/em&gt;&lt;span&gt;)-γ-norleucine is a highly selective inhibitor of GV sPLA&lt;/span&gt;&lt;sub&gt;&lt;span&gt;2&lt;/span&gt;&lt;/sub&gt;&lt;span&gt;.&lt;/span&gt;</style></abstract><issue><style face="normal" font="default" size="100%">24</style></issue><auth-address><style face="normal" font="default" size="100%">Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens, 15771, GreeceDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0601, United StatesChemical Laboratories, Agricultural University of Athens, Athens, 11855, Greece</style></auth-address></record></records></xml>