<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Constantinou-Kokotou, Violetta</style></author><author><style face="normal" font="default" size="100%">Magrioti, Victoria</style></author><author><style face="normal" font="default" size="100%">Verger, Robert</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sterically Hindered Triacylglycerol Analogues as Potent Inhibitors of Human Digestive Lipases</style></title><secondary-title><style face="normal" font="default" size="100%">Chemistry - A European Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enzyme Inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipids</style></keyword><keyword><style  face="normal" font="default" size="100%">monolayers</style></keyword><keyword><style  face="normal" font="default" size="100%">triacylglycerol analogues</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2004</style></year></dates><number><style face="normal" font="default" size="100%">5</style></number><publisher><style face="normal" font="default" size="100%">WILEY-VCH Verlag</style></publisher><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1133-1140</style></pages><isbn><style face="normal" font="default" size="100%">1521-3765</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;span&gt;A novel class of inhibitors of human digestive lipases have been developed. Various sterically hindered triacylglycerols based on 2-methyl- and 2-butylglycerol, and/or 2-methyl fatty acids were synthesized. The triacylglycerol analogues were tested for their ability to form stable monomolecular films at the air/water interface by recording their surface-pressure/molecular-area compression isotherms. The inhibition of human pancreatic and gastric lipases by the sterically hindered triacylglycerol analogues was studied by using the monolayer technique with mixed films of 1,2-dicaprin, which contained variable proportions of each inhibitor. Triolein analogues that contain a butyl group at the 2-position of the glycerol backbone or methyl groups both at the 2-position of glycerol, and the α-position of each oleic acid residue were potent inhibitors; this caused a 50 % decrease in HPL activity at 0.003 molar fraction.&lt;/span&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue></record></records></xml>