@article {17353,
	title = {Molecular Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals in a Network-Based Intervention (Transmission Reduction Intervention Project): Phylogenetics Identify HIV-1-Infected Individuals With Social Links},
	journal = {J Infect Dis},
	volume = {218},
	number = {5},
	year = {2018},
	note = {Kostaki, Evangelia-GeorgiaNikolopoulos, Georgios KPavlitina, EiriniWilliams, LeslieMagiorkinis, GkikasSchneider, JohnSkaathun, BrittMorgan, EthanPsichogiou, MinaDaikos, Georgios LSypsa, VanaSmyrnov, PavloKorobchuk, AniaMalliori, MeniHatzakis, AngelosFriedman, Samuel RParaskevis, DimitriosengP30 DA011041/DA/NIDA NIH HHS/T32 AI007384/AI/NIAID NIH HHS/DP1 DA034989/DA/NIDA NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}t2018/04/27 06:00J Infect Dis. 2018 Jul 24;218(5):707-715. doi: 10.1093/infdis/jiy239.},
	month = {Jul 24},
	pages = {707-715},
	abstract = {Background: The Transmission Reduction Intervention Project (TRIP) is a network-based intervention that aims at decreasing human immunodeficiency virus type 1 (HIV-1) spread. We herein explore associations between transmission links as estimated by phylogenetic analyses, and social network-based ties among persons who inject drugs (PWID) recruited in TRIP. Methods: Phylogenetic trees were inferred from HIV-1 sequences of TRIP participants. Highly supported phylogenetic clusters (transmission clusters) were those fulfilling 3 different phylogenetic confidence criteria. Social network-based ties (injecting or sexual partners, same venue engagement) were determined based on personal interviews, recruitment links, and field observation. Results: TRIP recruited 356 individuals (90.2\% PWID) including HIV-negative controls; recently HIV-infected seeds; long-term HIV-infected seeds; and their social network members. Of the 150 HIV-infected participants, 118 (78.7\%) were phylogenetically analyzed. Phylogenetic analyses suggested the existence of 13 transmission clusters with 32 sequences. Seven of these clusters included 14 individuals (14/32 [43.8\%]) who also had social ties with at least 1 member of their cluster. This proportion was significantly higher than what was expected by chance. Conclusions: Molecular methods can identify HIV-infected people socially linked with another person in about half of the phylogenetic clusters. This could help public health efforts to locate individuals in networks with high transmission rates.},
	keywords = {*Disease Transmission, Infectious, *Genotype, *Social Networking, Adolescent, Adult, Aged, Aged, 80 and over, Cluster analysis, Drug Users, Female, Genotyping Techniques, HIV Infections/*epidemiology/*transmission, HIV-1/*classification/*genetics/isolation \& purification, Humans, Male, Middle Aged, molecular epidemiology, Phylogeny, Sequence Analysis, DNA, Substance Abuse, Intravenous/complications, Surveys and Questionnaires, Young Adult},
	isbn = {1537-6613 (Electronic)0022-1899 (Linking)},
	author = {Kostaki, E. G. and Nikolopoulos, G K and Pavlitina, E. and Williams, L. and Magiorkinis, G and Schneider, J. and Skaathun, B. and Morgan, E. and Psichogiou, M and Daikos, G L and Sypsa, V and Smyrnov, P. and Korobchuk, A. and Malliori, M. and Hatzakis, A and Friedman, S. R. and Paraskevis, D}
}
