@article {17363,
	title = {PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy},
	journal = {J Hepatol},
	volume = {64},
	number = {4},
	year = {2016},
	note = {Papatheodoridis, GeorgeDalekos, GeorgeSypsa, VanaYurdaydin, CihanButi, MariaGoulis, JohnCalleja, Jose LuisChi, HengManolakopoulos, SpiliosMangia, GiampaoloGatselis, NikolaosKeskin, OnurSavvidou, Savvoulade la Revilla, JuanHansen, Bettina EVlachogiannakos, IoannisGalanis, KostantinosIdilman, RamazanColombo, MassimoEsteban, RafaelJanssen, Harry L ALampertico, PietroengMulticenter StudyNetherlands2015/12/19 06:00J Hepatol. 2016 Apr;64(4):800-6. doi: 10.1016/j.jhep.2015.11.035. Epub 2015 Dec 8.},
	month = {Apr},
	pages = {800-6},
	abstract = {BACKGROUND \&amp; AIMS: Risk scores for hepatocellular carcinoma (HCC) developed in Asians offer poor-moderate predictability in Caucasian patients with chronic hepatitis B (CHB). This nine center cohort study aimed to develop and validate an accurate HCC risk score in Caucasian CHB patients treated with the current oral antivirals, entecavir/tenofovir. METHODS: We included 1815 adult Caucasians with CHB and no HCC at baseline who received entecavir/tenofovir for 12 months. Using data from eight centers (derivation dataset, n=1325), a HCC risk score was developed based on multivariable Cox models and points system for simplification. Harrell{\textquoteright}s c-index was used as discrimination, bootstrap for internal validation and the data from the 9(th) and largest center (validation dataset, n=490) for external validation. RESULTS: The 5-year cumulative HCC incidence rates were 5.7\% and 8.4\% in the derivation and validation dataset, respectively. In the derivation dataset, age, gender, platelets and cirrhosis were independently associated with HCC. The PAGE-B score was developed based on age, gender and platelets (c-index=0.82, 0.81 after bootstrap validation). The addition of cirrhosis did not substantially improve the discrimination (c-index=0.84). The predictability of PAGE-B score was similar (c-index=0.82) in the validation dataset. Patients with PAGE-B 9, 10-17, 18 had 5-year cumulative HCC incidence rates of 0\%, 3\%, 17\% in the derivation and 0\%, 4\%, 16\% in the validation dataset. CONCLUSION: PAGE-B, which is based only on baseline patients{\textquoteright} age, gender and platelets, represents a simple and reliable score for prediction of the 5-year HCC risk in Caucasian CHB patients under entecavir/tenofovir.},
	keywords = {Adult, Aged, Antiviral Agents/*therapeutic use, Carcinoma, Hepatocellular/*etiology, Cohort Studies, Female, Guanine/administration \& dosage/analogs \& derivatives, Hepatitis B, Chronic/complications/*drug therapy, Humans, Liver Neoplasms/*etiology, Male, Middle Aged, Proportional Hazards Models, Risk, Tenofovir/administration \& dosage},
	isbn = {1600-0641 (Electronic)0168-8278 (Linking)},
	author = {Papatheodoridis, G. and G Dalekos and Sypsa, V and Yurdaydin, C. and Buti, M. and Goulis, J. and Calleja, J. L. and Chi, H. and Manolakopoulos, S. and Mangia, G. and N Gatselis and Keskin, O. and Savvidou, S. and de la Revilla, J. and Hansen, B. E. and Vlachogiannakos, I. and Galanis, K. and Idilman, R. and Colombo, M. and Esteban, R. and Janssen, H. L. and Lampertico, P.}
}
