@article {17377,
	title = {A case-control study of MC1R variants in Greek patients with basal cell carcinoma: increased risk independently of pigmentary characteristics},
	journal = {Exp Dermatol},
	volume = {24},
	number = {6},
	year = {2015},
	note = {Dessinioti, ClioSypsa, VanaKypreou, KaterinaDimisianos, GerasimosKodela, ElisavetNikolaou, VasilikiAntoniou, ChristinaStratigos, Alexander JengLetterDenmark2015/03/27 06:00Exp Dermatol. 2015 Jun;24(6):476-8. doi: 10.1111/exd.12703. Epub 2015 Apr 16.},
	month = {Jun},
	pages = {476-8},
	abstract = {Melanocortin 1 receptor (MC1R) gene variants are a major contributor to pigmentation characteristics and the modulation of sporadic basal cell carcinoma (BCC) risk. This is a hospital-based, case-control study to investigate the association of MC1R variants and pigmentary characteristics with the risk of BCC development in a Southern European population in Greece. In total, 141 patients with BCC and 166 controls were studied. Increased BCC risk was found for the presence of 2 or more MC1R variants (OR:3.07, 95\% CI:1.13-8.34), or 2 or more variants of which at least 1 was major function (OR:7.15, 95\% CI:1.37-5.52), after adjustment for the {\textquoteright}red hair colour{\textquoteright} (RHC) phenotype. Increased BCC risk persisted in the presence of 2 or more MC1R variants (OR:4.15, 95\% CI:1.35-12.72), after adjustment for potential confounding factors including skin color (P:0.237) and atypical nevi (OR:9.57, 95\% CI:2.19-41.81, P:0.003). MC1R genotype is a risk factor for the development of BCC in Greek patients independently of pigmentary characteristics, and the combination of MC1R variants may modulate this risk.},
	keywords = {Adult, Aged, Carcinoma, Basal Cell/ethnology/*genetics, Case-Control Studies, Female, Genetic Predisposition to Disease/ethnology/genetics, Genetic Variation/*genetics, Genotype, Greece, Hair Color/genetics, Humans, Male, Middle Aged, Phenotype, Pigmentation/*genetics/physiology, Receptor, Melanocortin, Type 1/*genetics, Risk Factors, Skin Neoplasms/ethnology/*genetics},
	isbn = {1600-0625 (Electronic)0906-6705 (Linking)},
	author = {Dessinioti, C. and Sypsa, V and Kypreou, K. and Dimisianos, G. and Kodela, E. and Nikolaou, V and Antoniou, C. and Stratigos, A. J.}
}
