@article {17404,
	title = {Impact of hepatitis B virus infection on the progression of AIDS and mortality in HIV-infected individuals: a cohort study and meta-analysis},
	journal = {Clin Infect DisClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaClinical infectious diseases : an official publication of the Infectious Diseases Society of America},
	volume = {48},
	number = {12},
	year = {2009},
	note = {Nikolopoulos, Georgios KParaskevis, DimitriosHatzitheodorou, EleniMoschidis, ZissisSypsa, VanaZavitsanos, XenophonKalapothaki, VictoriaHatzakis, AngelosengMeta-AnalysisResearch Support, Non-U.S. Gov{\textquoteright}t2009/05/14 09:00Clin Infect Dis. 2009 Jun 15;48(12):1763-71. doi: 10.1086/599110.},
	month = {Jun 15},
	pages = {1763-71},
	abstract = {BACKGROUND: The effect of hepatitis B virus (HBV) infection on the natural history of human immunodeficiency virus (HIV) disease remains uncertain. Therefore, a retrospective cohort study was conducted to examine the influence of HIV-HBV coinfection on AIDS development and overall mortality. Moreover, our results were added to those of previous studies in a literature-based meta-analysis. METHODS: Serum samples obtained from HIV-seropositive patients from 1984 through 2003 were retrospectively tested for hepatitis B surface antigen. Multivariable analyses were performed using Poisson and logistic regression models. For meta-analytic purposes, eligible articles were identified and relevant data were abstracted. Pooled estimates of effect were calculated applying fixed and random effects models. RESULTS: The prevalence of chronic HBV infection (documented hepatitis B surface antigen seropositivity for >6 months) among 1729 HIV-positive patients was approximately 6\%. The multivariable analyses in our primary study revealed no significant impact of concomitant HIV-HBV infection on progression to AIDS and all-cause mortality. However, a meta-analysis performed on data from 12,382 patients enrolled in 11 studies revealed a significant effect of HIV-HBV coinfection on overall mortality (pooled effect estimate, 1.36; 95\% confidence interval, 1.12-1.64). The increased rate of death among coinfected individuals was observed in the meta-analyses of studies conducted both before (pooled effect estimate, 1.60; 95\% confidence interval, 1.07-2.39) and after (pooled effect estimate, 1.28; 95\% confidence interval, 1.03-1.60) commencement of highly active antiretroviral therapy. CONCLUSIONS: HIV-HBV coinfection seems to affect all-cause mortality, and strategies to reduce liver damage in patients coinfected with HIV and HBV are justified.},
	keywords = {Acquired Immunodeficiency Syndrome/*complications/epidemiology/*mortality, Adult, Cohort Studies, Disease Progression, Female, Hepatitis B Surface Antigens/blood, Hepatitis B, Chronic/*complications/epidemiology/mortality, Humans, Male, Prevalence, Retrospective Studies, Serum/virology},
	isbn = {1537-6591 (Electronic)1058-4838 (Linking)},
	author = {Nikolopoulos, G K and Paraskevis, D and Hatzitheodorou, E. and Moschidis, Z. and Sypsa, V and Zavitsanos, X. and Kalapothaki, V and Hatzakis, A}
}
