@article {17413,
	title = {Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic history and origin},
	journal = {J Infect DisThe Journal of infectious diseasesThe Journal of infectious diseases},
	volume = {196},
	number = {8},
	year = {2007},
	note = {Paraskevis, DimitriosMagiorkinis, EmmanouilMagiorkinis, GkikasSypsa, VanaPaparizos, VassiliosLazanas, MariosGargalianos, PanagiotisAntoniadou, AnastasiaPanos, GeorgiosChrysos, GeorgiosSambatakou, HelenKarafoulidou, AnastasiaSkoutelis, AthanasiosKordossis, TheodorosKoratzanis, GeorgiosTheodoridou, MariaDaikos, Georgios LNikolopoulos, GeorgiosPybus, Oliver GHatzakis, AngelosengResearch Support, Non-U.S. Gov{\textquoteright}t2007/10/24 09:00J Infect Dis. 2007 Oct 15;196(8):1167-76. doi: 10.1086/521677. Epub 2007 Sep 13.},
	month = {Oct 15},
	pages = {1167-76},
	abstract = {BACKGROUND: In North America and Europe, human immunodeficiency virus (HIV)-1 infection has typically been dominated by subtype B transmission. More recently, however, non-B subtypes have been increasingly reported in Europe. METHODS: We analyzed 1158 HIV-1-infected individuals in Greece by DNA sequencing and phylogenetic analyses of protease and partial reverse-transcriptase regions. RESULTS: We found that the prevalence of non-B subtypes has increased over time and that this significant trend can be mainly attributed to subtype A, which eventually surpassed subtype B in prevalence in 2004 (42\% and 33\%, respectively). Multivariate analysis revealed that the year of HIV diagnosis was independently associated with subtype A infection (odds ratio for being infected with subtype A for a 10-year increase in the time period of diagnosis, 2.09 [95\% confidence interval, 1.36-3.24]; P<.001). Phylogenetic analysis revealed that the subtype A epidemic in Greece is the result of a single founder event. The date of the most recent common ancestor of the subtype A in Greece was estimated to be 1977.9 (95\% highest posterior density interval, 1973.7-1981.9). CONCLUSIONS: Subtype A circulates among the long-term residents of Greece. This is in contrast to the situation in most European countries, in which infection with non-B genetic forms is associated either with being an immigrant or heterosexual or with intravenous drug use.},
	keywords = {*Genetic Variation, Adult, Female, Greece/epidemiology, HIV Infections/epidemiology/*genetics, HIV Protease/genetics, HIV Reverse Transcriptase/genetics, HIV-1/classification/*genetics, Humans, Male, Middle Aged, Phylogeny, Prevalence},
	isbn = {0022-1899 (Print)0022-1899 (Linking)},
	author = {Paraskevis, D and Magiorkinis, E and Magiorkinis, G and Sypsa, V and Paparizos, V and Lazanas, M and Gargalianos, P and Antoniadou, A and Panos, G. and Chrysos, G and Sambatakou, H and Karafoulidou, A. and Skoutelis, A and Kordossis, T. and Koratzanis, G and Theodoridou, M. and Daikos, G L and Nikolopoulos, G. and Pybus, O. G. and Hatzakis, A and Multicentre Study on, H. I. V. Heterogeneity}
}
