@article {17419,
	title = {Evaluation of the clinical sensitivity for the quantification of human immunodeficiency virus type 1 RNA in plasma: Comparison of the new COBAS TaqMan HIV-1 with three current HIV-RNA assays--LCx HIV RNA quantitative, VERSANT HIV-1 RNA 3.0 (bDNA) and COBA},
	journal = {J Virol MethodsJ Virol MethodsJ Virol Methods},
	volume = {131},
	number = {2},
	year = {2006},
	note = {Katsoulidou, AntigoniPetrodaskalaki, MariaSypsa, VanaPapachristou, EleniAnastassopoulou, Cleo GGargalianos, PanagiotisKarafoulidou, AnastasiaLazanas, MariosKordossis, TheodorosAndoniadou, AnastasiaHatzakis, AngelosengComparative StudyEvaluation StudyNetherlands2005/10/01 09:00J Virol Methods. 2006 Feb;131(2):168-74. doi: 10.1016/j.jviromet.2005.07.014. Epub 2005 Sep 27.},
	month = {Feb},
	pages = {168-74},
	abstract = {The COBAS TaqMan HIV-1 test (Roche Diagnostics) was compared with the LCx HIV RNA quantitative assay (Abbott Laboratories), the Versant HIV-1 RNA 3.0 (bDNA) assay (Bayer) and the COBAS Amplicor HIV-1 Monitor v1.5 test (Roche Diagnostics), using plasma samples of various viral load levels from HIV-1-infected individuals. In the comparison of TaqMan with LCx, TaqMan identified as positive 77.5\% of the 240 samples versus 72.1\% identified by LCx assay, while their overall agreement was 94.6\% and the quantitative results of samples that were positive by both methods were strongly correlated (r=0.91). Similarly, in the comparison of TaqMan with bDNA 3.0, both methods identified 76.3\% of the 177 samples as positive, while their overall agreement was 95.5\% and the quantitative results of samples that were positive by both methods were strongly correlated (r=0.95). Finally, in the comparison of TaqMan with Monitor v1.5, TaqMan identified 79.5\% of the 156 samples as positive versus 80.1\% identified by Monitor v1.5, while their overall agreement was 95.5\% and the quantitative results of samples that were positive by both methods were strongly correlated (r=0.96). In conclusion, the new COBAS TaqMan HIV-1 test showed excellent agreement with other widely used commercially available tests for the quantitation of HIV-1 viral load.},
	keywords = {*Viral Load, HIV Infections/*virology, HIV-1/isolation \& purification/*physiology, Humans, Reagent Kits, Diagnostic, RNA, Viral/*blood, Sensitivity and Specificity, Statistics as Topic},
	isbn = {0166-0934 (Print)0166-0934 (Linking)},
	author = {Katsoulidou, A and Petrodaskalaki, M. and Sypsa, V and Papachristou, E. and Anastassopoulou, C. G. and Gargalianos, P and Karafoulidou, A. and Lazanas, M and Kordossis, T. and Andoniadou, A. and Hatzakis, A}
}
