@article {17431,
	title = {In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity},
	journal = {J Gen VirolJ Gen VirolJ Gen Virol},
	volume = {84},
	number = {Pt 10},
	year = {2003},
	note = {Magiorkinis, GkikasParaskevis, DimitriosVandamme, Anne-MiekeMagiorkinis, EmmanouilSypsa, VanaHatzakis, AngelosengEngland2003/09/19 05:00J Gen Virol. 2003 Oct;84(Pt 10):2715-22. doi: 10.1099/vir.0.19180-0.},
	month = {Oct},
	pages = {2715-22},
	abstract = {Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model.},
	keywords = {*Evolution, Molecular, *Recombination, Genetic, Genome, Viral, HIV Envelope Protein gp41/genetics, HIV Reverse Transcriptase/genetics, HIV-1/classification/*genetics, Humans, Repetitive Sequences, Nucleic Acid, Sequence Alignment, Viral Proteins/*genetics},
	isbn = {0022-1317 (Print)0022-1317 (Linking)},
	author = {Magiorkinis, G and Paraskevis, D and Vandamme, A. M. and Magiorkinis, E and Sypsa, V and Hatzakis, A}
}
