<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nikolopoulos, G K</style></author><author><style face="normal" font="default" size="100%">Katsoulidou, A</style></author><author><style face="normal" font="default" size="100%">Kantzanou, M</style></author><author><style face="normal" font="default" size="100%">Rokka, C</style></author><author><style face="normal" font="default" size="100%">Tsiara, C</style></author><author><style face="normal" font="default" size="100%">Sypsa, V</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Psichogiou, M</style></author><author><style face="normal" font="default" size="100%">Friedman, S</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the limiting antigen avidity EIA (LAg) in people who inject drugs in Greece</style></title><secondary-title><style face="normal" font="default" size="100%">Epidemiol Infect</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Epidemiology and infection</style></alt-title><short-title><style face="normal" font="default" size="100%">Epidemiology and infectionEpidemiology and infection</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Antibody Affinity</style></keyword><keyword><style  face="normal" font="default" size="100%">*Diagnostic Errors</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Greece</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Antibodies/*blood</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections/*diagnosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunoenzyme Techniques/*methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Viral/blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Substance Abuse, Intravenous/*complications</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Load</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><volume><style face="normal" font="default" size="100%">145</style></volume><pages><style face="normal" font="default" size="100%">401-412</style></pages><isbn><style face="normal" font="default" size="100%">1469-4409 (Electronic)0950-2688 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) 1.5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected &amp;gt;6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons. The PTR was 85.7%. The PFR was 20.8% but fell to 5.9% in samples from treatment-naive individuals with long-standing infection (&amp;gt;1 year), and to 0 in samples with the circulating recombinant form CRF35 AD. A LAg-based algorithm with a PFR of 3.3% estimated a similar incidence trend to that calculated by analyses based on HIV-1 seroconversions. In recently infected persons indicated by LAg, the median log10 HIV RNA level was high (5.30, interquartile range 4.56-5.90). LAg can help identify highly infectious HIV(+) individuals as it accurately identifies recent infections and is correlated with the HIV RNA level. It can also produce reliable estimates of HIV-1 incidence.</style></abstract><accession-num><style face="normal" font="default" size="100%">27780490</style></accession-num><notes><style face="normal" font="default" size="100%">Nikolopoulos, G KKatsoulidou, AKantzanou, MRokka, CTsiara, CSypsa, VParaskevis, DPsichogiou, MFriedman, SHatzakis, AengDP1 DA034989/DA/NIDA NIH HHS/P30 DA011041/DA/NIDA NIH HHS/Evaluation StudyEngland2016/10/27 06:00Epidemiol Infect. 2017 Jan;145(2):401-412. doi: 10.1017/S0950268816002417. Epub 2016 Oct 26.</style></notes><custom2><style face="normal" font="default" size="100%">6824880</style></custom2><auth-address><style face="normal" font="default" size="100%">Medical School,University of Cyprus,Nicosia,Cyprus.Department of Hygiene,Epidemiology and Medical Statistics,Medical School,University of Athens,Athens,Greece.Hellenic Centre for Disease Control and Prevention,Amarousio,Greece.First Department of Internal Medicine,Laiko General Hospital,University of Athens,Athens,Greece.National Development and Research Institutes (NDRI),New York,USA.</style></auth-address></record></records></xml>