<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karamitros, T.</style></author><author><style face="normal" font="default" size="100%">Papatheodoridis, G.</style></author><author><style face="normal" font="default" size="100%">Dimopoulou, E.</style></author><author><style face="normal" font="default" size="100%">Papageorgiou, M. V.</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Magiorkinis, G</style></author><author><style face="normal" font="default" size="100%">Sypsa, V</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The interferon receptor-1 promoter polymorphisms affect the outcome of Caucasians with HBeAg-negative chronic HBV infection</style></title><secondary-title><style face="normal" font="default" size="100%">Liver IntLiver IntLiver Int</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Liver international : official journal of the International Association for the Study of the Liver</style></alt-title><short-title><style face="normal" font="default" size="100%">Liver international : official journal of the International Association for the Study of the LiverLiver international : official journal of the International Association for the Study of the Liver</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Hepatitis B, Chronic/genetics/virology</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis B e Antigens/*blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis B virus/*immunology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Promoter Regions, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor, Interferon alpha-beta/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Dec</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">12</style></number><volume><style face="normal" font="default" size="100%">35</style></volume><pages><style face="normal" font="default" size="100%">2506-13</style></pages><isbn><style face="normal" font="default" size="100%">1478-3231 (Electronic)1478-3223 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND &amp; AIMS: The outcome of HBeAg-negative chronic hepatitis B virus (HBV) patients who may remain in the inactive carrier state (IC) or progress to HBeAg-negative chronic hepatitis B may be affected by the host genetic profile. Genetic polymorphisms within not only the promoter but also the coding sequence of the interferon receptor 1 (INFAR1) gene have been associated with susceptibility to chronic HBV infection, but their role on the outcomes of HBeAg-negative patients has not been evaluated. We examined the association of INFAR1 promoter polymorphisms with the phase of chronic HBV infection in a demographically characterized Caucasian cohort of 183 consecutive HBeAg-negative chronic HBV patients. METHODS: Using a combination of conventional and allele-specific polymerase chain reactions, bidirectional sequencing and DNA-fragment analysis, we performed typing of three Single Nucleotide Polymorphisms (SNPs -568G/C, -408C/T, -3C/T) and one Variable Number Tandem Repeat [VNTR -77(GT)n] within the INFR1 promoter sequence. RESULTS: The genetic polymorphisms examined were found to be associated with the phase of HBeAg-negative chronic HBV patients. Using a multiple logistic regression model adjusting for age, gender and origin of the individuals, we found that patients with linked genotypes -408CT_-3CT were more likely to be ICs (OR = 2.42 vs. CC, P = 0.036). Also, given the partial linkage between SNP -568G/C and VNTR -77(GT)n, we found that linked genotypes -77(GT)n &lt;/= 8/&lt;/=8_-568GC and -77(GT)n &lt;/= 8/&lt;/=8_-568CC were detected more frequently among ICs (OR = 11.69, P = 0.005 and OR = 7.56, P = 0.001 vs. -77(GT)n &gt;8/&gt;8_-568GG respectively). CONCLUSIONS: These findings suggest that these genetic variations represent important factors associated with the clinical phase of HBeAg-negative chronic HBV infection.</style></abstract><accession-num><style face="normal" font="default" size="100%">25939635</style></accession-num><notes><style face="normal" font="default" size="100%">Karamitros, TimokratisPapatheodoridis, GeorgeDimopoulou, EleniPapageorgiou, Maria-VasilikiParaskevis, DimitriosMagiorkinis, GkikasSypsa, VanaHatzakis, AngelosengResearch Support, Non-U.S. Gov't2015/05/06 06:00Liver Int. 2015 Dec;35(12):2506-13. doi: 10.1111/liv.12859. Epub 2015 May 17.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Hygiene and Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.Department of Zoology, University of Oxford, Oxford, UK.2nd Department of Internal Medicine, Hippokration General Hospital, Athens University Medical School, Athens, Greece.Academic Department of Gastroenterology, Laiko General Hospital, Athens University Medical School, Athens, Greece.</style></auth-address></record></records></xml>