<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dessinioti, C.</style></author><author><style face="normal" font="default" size="100%">Sypsa, V</style></author><author><style face="normal" font="default" size="100%">Kypreou, K.</style></author><author><style face="normal" font="default" size="100%">Dimisianos, G.</style></author><author><style face="normal" font="default" size="100%">Kodela, E.</style></author><author><style face="normal" font="default" size="100%">Nikolaou, V</style></author><author><style face="normal" font="default" size="100%">Antoniou, C.</style></author><author><style face="normal" font="default" size="100%">Stratigos, A. J.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A case-control study of MC1R variants in Greek patients with basal cell carcinoma: increased risk independently of pigmentary characteristics</style></title><secondary-title><style face="normal" font="default" size="100%">Exp Dermatol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Experimental dermatology</style></alt-title><short-title><style face="normal" font="default" size="100%">Experimental dermatologyExperimental dermatology</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Carcinoma, Basal Cell/ethnology/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Case-Control Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease/ethnology/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Greece</style></keyword><keyword><style  face="normal" font="default" size="100%">Hair Color/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Pigmentation/*genetics/physiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Receptor, Melanocortin, Type 1/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin Neoplasms/ethnology/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jun</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">6</style></number><volume><style face="normal" font="default" size="100%">24</style></volume><pages><style face="normal" font="default" size="100%">476-8</style></pages><isbn><style face="normal" font="default" size="100%">1600-0625 (Electronic)0906-6705 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Melanocortin 1 receptor (MC1R) gene variants are a major contributor to pigmentation characteristics and the modulation of sporadic basal cell carcinoma (BCC) risk. This is a hospital-based, case-control study to investigate the association of MC1R variants and pigmentary characteristics with the risk of BCC development in a Southern European population in Greece. In total, 141 patients with BCC and 166 controls were studied. Increased BCC risk was found for the presence of 2 or more MC1R variants (OR:3.07, 95% CI:1.13-8.34), or 2 or more variants of which at least 1 was major function (OR:7.15, 95% CI:1.37-5.52), after adjustment for the 'red hair colour' (RHC) phenotype. Increased BCC risk persisted in the presence of 2 or more MC1R variants (OR:4.15, 95% CI:1.35-12.72), after adjustment for potential confounding factors including skin color (P:0.237) and atypical nevi (OR:9.57, 95% CI:2.19-41.81, P:0.003). MC1R genotype is a risk factor for the development of BCC in Greek patients independently of pigmentary characteristics, and the combination of MC1R variants may modulate this risk.</style></abstract><accession-num><style face="normal" font="default" size="100%">25809071</style></accession-num><notes><style face="normal" font="default" size="100%">Dessinioti, ClioSypsa, VanaKypreou, KaterinaDimisianos, GerasimosKodela, ElisavetNikolaou, VasilikiAntoniou, ChristinaStratigos, Alexander JengLetterDenmark2015/03/27 06:00Exp Dermatol. 2015 Jun;24(6):476-8. doi: 10.1111/exd.12703. Epub 2015 Apr 16.</style></notes><auth-address><style face="normal" font="default" size="100%">Dermato-Oncology Unit, 1st Department of Dermatology, University of Athens, Andreas Sygros Hospital, Athens, Greece.Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.Department of Medical Genetics, University of Athens Medical School, Agia Sophia Children's Hospital, Athens, Greece.</style></auth-address></record></records></xml>