<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Magiorkinis, E</style></author><author><style face="normal" font="default" size="100%">Magiorkinis, G</style></author><author><style face="normal" font="default" size="100%">Sypsa, V</style></author><author><style face="normal" font="default" size="100%">Paparizos, V</style></author><author><style face="normal" font="default" size="100%">Lazanas, M</style></author><author><style face="normal" font="default" size="100%">Gargalianos, P</style></author><author><style face="normal" font="default" size="100%">Antoniadou, A</style></author><author><style face="normal" font="default" size="100%">Panos, G.</style></author><author><style face="normal" font="default" size="100%">Chrysos, G</style></author><author><style face="normal" font="default" size="100%">Sambatakou, H</style></author><author><style face="normal" font="default" size="100%">Karafoulidou, A.</style></author><author><style face="normal" font="default" size="100%">Skoutelis, A</style></author><author><style face="normal" font="default" size="100%">Kordossis, T.</style></author><author><style face="normal" font="default" size="100%">Koratzanis, G</style></author><author><style face="normal" font="default" size="100%">Theodoridou, M.</style></author><author><style face="normal" font="default" size="100%">Daikos, G L</style></author><author><style face="normal" font="default" size="100%">Nikolopoulos, G.</style></author><author><style face="normal" font="default" size="100%">Pybus, O. G.</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author><author><style face="normal" font="default" size="100%">Multicentre Study on, H. I. V. Heterogeneity</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic history and origin</style></title><secondary-title><style face="normal" font="default" size="100%">J Infect DisThe Journal of infectious diseasesThe Journal of infectious diseases</style></secondary-title><alt-title><style face="normal" font="default" size="100%">The Journal of infectious diseases</style></alt-title><short-title><style face="normal" font="default" size="100%">J Infect DisJ Infect Dis</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Greece/epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Infections/epidemiology/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Protease/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Reverse Transcriptase/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV-1/classification/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Phylogeny</style></keyword><keyword><style  face="normal" font="default" size="100%">Prevalence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 15</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><volume><style face="normal" font="default" size="100%">196</style></volume><pages><style face="normal" font="default" size="100%">1167-76</style></pages><isbn><style face="normal" font="default" size="100%">0022-1899 (Print)0022-1899 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND: In North America and Europe, human immunodeficiency virus (HIV)-1 infection has typically been dominated by subtype B transmission. More recently, however, non-B subtypes have been increasingly reported in Europe. METHODS: We analyzed 1158 HIV-1-infected individuals in Greece by DNA sequencing and phylogenetic analyses of protease and partial reverse-transcriptase regions. RESULTS: We found that the prevalence of non-B subtypes has increased over time and that this significant trend can be mainly attributed to subtype A, which eventually surpassed subtype B in prevalence in 2004 (42% and 33%, respectively). Multivariate analysis revealed that the year of HIV diagnosis was independently associated with subtype A infection (odds ratio for being infected with subtype A for a 10-year increase in the time period of diagnosis, 2.09 [95% confidence interval, 1.36-3.24]; P&lt;.001). Phylogenetic analysis revealed that the subtype A epidemic in Greece is the result of a single founder event. The date of the most recent common ancestor of the subtype A in Greece was estimated to be 1977.9 (95% highest posterior density interval, 1973.7-1981.9). CONCLUSIONS: Subtype A circulates among the long-term residents of Greece. This is in contrast to the situation in most European countries, in which infection with non-B genetic forms is associated either with being an immigrant or heterosexual or with intravenous drug use.</style></abstract><accession-num><style face="normal" font="default" size="100%">17955435</style></accession-num><notes><style face="normal" font="default" size="100%">Paraskevis, DimitriosMagiorkinis, EmmanouilMagiorkinis, GkikasSypsa, VanaPaparizos, VassiliosLazanas, MariosGargalianos, PanagiotisAntoniadou, AnastasiaPanos, GeorgiosChrysos, GeorgiosSambatakou, HelenKarafoulidou, AnastasiaSkoutelis, AthanasiosKordossis, TheodorosKoratzanis, GeorgiosTheodoridou, MariaDaikos, Georgios LNikolopoulos, GeorgiosPybus, Oliver GHatzakis, AngelosengResearch Support, Non-U.S. Gov't2007/10/24 09:00J Infect Dis. 2007 Oct 15;196(8):1167-76. doi: 10.1086/521677. Epub 2007 Sep 13.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Hygiene and Epidemiology, National Retrovirus Reference Center, Athens, Greece.</style></auth-address></record></records></xml>