<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Magiorkinis, G</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Vandamme, A. M.</style></author><author><style face="normal" font="default" size="100%">Magiorkinis, E</style></author><author><style face="normal" font="default" size="100%">Sypsa, V</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity</style></title><secondary-title><style face="normal" font="default" size="100%">J Gen VirolJ Gen VirolJ Gen Virol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">The Journal of general virology</style></alt-title><short-title><style face="normal" font="default" size="100%">The Journal of general virologyThe Journal of general virology</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Evolution, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">*Recombination, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Viral</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Envelope Protein gp41/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV Reverse Transcriptase/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV-1/classification/*genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Repetitive Sequences, Nucleic Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence Alignment</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Proteins/*genetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2003</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">Pt 10</style></number><volume><style face="normal" font="default" size="100%">84</style></volume><pages><style face="normal" font="default" size="100%">2715-22</style></pages><isbn><style face="normal" font="default" size="100%">0022-1317 (Print)0022-1317 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model.</style></abstract><accession-num><style face="normal" font="default" size="100%">13679605</style></accession-num><notes><style face="normal" font="default" size="100%">Magiorkinis, GkikasParaskevis, DimitriosVandamme, Anne-MiekeMagiorkinis, EmmanouilSypsa, VanaHatzakis, AngelosengEngland2003/09/19 05:00J Gen Virol. 2003 Oct;84(Pt 10):2715-22. doi: 10.1099/vir.0.19180-0.</style></notes><auth-address><style face="normal" font="default" size="100%">National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, 11527 Athens, Greece.</style></auth-address></record></records></xml>