<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anastassopoulou, C. G.</style></author><author><style face="normal" font="default" size="100%">Paraskevis, D</style></author><author><style face="normal" font="default" size="100%">Tassopoulos, N. C.</style></author><author><style face="normal" font="default" size="100%">Boletis, J.</style></author><author><style face="normal" font="default" size="100%">Sypsa, V. A.</style></author><author><style face="normal" font="default" size="100%">Hess, G.</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular epidemiology of GB virus C/hepatitis G virus in Athens, Greece</style></title><secondary-title><style face="normal" font="default" size="100%">J Med VirolJ Med VirolJ Med Virol</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Journal of medical virology</style></alt-title><short-title><style face="normal" font="default" size="100%">Journal of medical virologyJournal of medical virology</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*Molecular Epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">5' Untranslated Regions/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Aged, 80 and over</style></keyword><keyword><style  face="normal" font="default" size="100%">Biomarkers/blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Flaviviridae/*genetics/immunology/isolation &amp; purification</style></keyword><keyword><style  face="normal" font="default" size="100%">Greece/epidemiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis Antibodies/blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis, Viral, Human/*epidemiology/virology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Sequence Data</style></keyword><keyword><style  face="normal" font="default" size="100%">Phylogeny</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Viral/blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Sequence Analysis, DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Viral Envelope Proteins/immunology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2000</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">61</style></volume><pages><style face="normal" font="default" size="100%">319-26</style></pages><isbn><style face="normal" font="default" size="100%">0146-6615 (Print)0146-6615 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The relevance of GB virus C/hepatitis G virus (GBV-C/HGV) infections in liver pathology remains unclear. To investigate the epidemiology of GBV-C/HGV in Athens, Greece, sera from 512 subjects were screened for present and past markers of GBV-C/HGV infection using a reverse transcription-polymerase chain reaction (RT-PCR) and a serological assay, respectively. GBV-C/HGV RNA was detected in 18/56 (32.1%), 12/42 (28.6%), and 16/55 (29.1%) patients with acute hepatitis B, C, or non-A-E, and in 5/58 (8.6%) and 18/68 (26.5%) patients with chronic hepatitis B or C, respectively, as well as in 50/133 (37.6%) hemodialysis patients and 10/100 (10%) healthy individuals. The data indicated that GBV-C/HGV seroprevalence is age-dependent; thus, GBV-C/HGV RNA and anti-E2 positivity were shown to be associated with younger age [odds ratio 0.98, 95% confidence interval (CI) 0. 97-1.00, P = 0.017] and older age (odds ratio 1.03, 95% CI 1.01-1.05, P = 0.002), respectively. No significant associations were identified between GBV-C/HGV RNA status and alanine aminotransferase (ALT) levels in either hepatitis or hemodialysis patients. Nevertheless, GBV-C/HGV RNA-positive acute non-A-E hepatitis patients were more likely to manifest a more severe clinical form of acute hepatitis (P = 0.024). Phylogenetic analysis of partial 5'-untranslated region sequences isolated from 18 viremic individuals showed that most GBV-C/HGV strains circulating in the greater metropolitan area of Athens belong to the 2a subgroup. A genetically diverse type 2 sequence that may represent a novel subtype within group 2 was also characterized.</style></abstract><accession-num><style face="normal" font="default" size="100%">10861639</style></accession-num><notes><style face="normal" font="default" size="100%">Anastassopoulou, C GParaskevis, DTassopoulos, N CBoletis, JSypsa, V AHess, GHatzakis, Aeng2000/06/22 10:00J Med Virol. 2000 Jul;61(3):319-26. doi: 10.1002/1096-9071(200007)61:3&lt;319::aid-jmv6&gt;3.0.co;2-r.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece.</style></auth-address></record></records></xml>