<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tassopoulos, N. C.</style></author><author><style face="normal" font="default" size="100%">Papatheodoridis, G. V.</style></author><author><style face="normal" font="default" size="100%">Katsoulidou, A</style></author><author><style face="normal" font="default" size="100%">Delladetsima, J. K.</style></author><author><style face="normal" font="default" size="100%">Sypsa, V</style></author><author><style face="normal" font="default" size="100%">Touloumi, G.</style></author><author><style face="normal" font="default" size="100%">Nikandros, M.</style></author><author><style face="normal" font="default" size="100%">Hatzakis, A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Factors associated with severity and disease progression in chronic hepatitis C</style></title><secondary-title><style face="normal" font="default" size="100%">HepatogastroenterologyHepatogastroenterologyHepatogastroenterology</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Hepato-gastroenterology</style></alt-title><short-title><style face="normal" font="default" size="100%">Hepato-gastroenterologyHepato-gastroenterology</style></short-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adult</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Progression</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepacivirus/genetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis C, Chronic/complications/*pathology/virology</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver Cirrhosis/etiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver/pathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA, Viral/analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1998</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Sep-Oct</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">23</style></number><volume><style face="normal" font="default" size="100%">45</style></volume><pages><style face="normal" font="default" size="100%">1678-83</style></pages><isbn><style face="normal" font="default" size="100%">0172-6390 (Print)0172-6390 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">BACKGROUND/AIMS: Chronic hepatitis C appears to have a highly variable natural course with 20% of patients developing cirrhosis within 20 years, while the majority of them run a relatively mild course. We studied the relationships of epidemiological, biochemical and virological features with histological severity (grade) and liver disease progression (stage). METHODOLOGY: Liver histology, serum HCV RNA level and HCV genotype were determined in a well-defined cohort of 152 consecutive (100 males, 52 females) patients with chronic hepatitis C. RESULTS: Patients with minimal or mild chronic hepatitis were significantly younger than those with moderate or severe chronic hepatitis (mean age: 41.1 vs 49.5 years respectively, p=0.003). On the other hand, patients with no or mild fibrosis compared to those with moderate or severe fibrosis and to those with cirrhosis were significantly more frequently males (73%, 64% and 43%, p=0.01), parenteral drug users (36%, 11% and 11%, p=0.01) and infected with other than 1b genotype (86%, 52% and 33%, p&lt;0.0001), significantly younger (mean age: 37, 48 and 58 years, p&lt;0.0001) and had significantly lower HCV RNA levels (geometric mean: 6.9, 19.2 and 17.5 x 10(5) eq/ml, p=0.007). Multivariate analysis showed that stage was significantly related only to patient age (p&lt;0.0001), HCV genotype (p=0.0025) and HCV RNA level (p=0.044). CONCLUSIONS: In chronic hepatitis C, histological severity seems to be associated only with patient age, while progression of the disease is mainly associated with patient age, HCV genotype and viremia level.</style></abstract><accession-num><style face="normal" font="default" size="100%">9840128</style></accession-num><notes><style face="normal" font="default" size="100%">Tassopoulos, N CPapatheodoridis, G VKatsoulidou, ADelladetsima, J KSypsa, VTouloumi, GNikandros, MHatzakis, AengGreece1998/12/05 00:00Hepatogastroenterology. 1998 Sep-Oct;45(23):1678-83.</style></notes><auth-address><style face="normal" font="default" size="100%">First Department of Medicine, Western Attica General Hospital, Athens, Greece.</style></auth-address></record></records></xml>