<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haubrich, Richard H.</style></author><author><style face="normal" font="default" size="100%">Flexner, Charles</style></author><author><style face="normal" font="default" size="100%">Lederman, Michael M.</style></author><author><style face="normal" font="default" size="100%">Hirsch, Martin</style></author><author><style face="normal" font="default" size="100%">Pettinelli, Carla P.</style></author><author><style face="normal" font="default" size="100%">Ginsberg, Richard</style></author><author><style face="normal" font="default" size="100%">Lietman, Paul</style></author><author><style face="normal" font="default" size="100%">Hamzeh, Fayez M.</style></author><author><style face="normal" font="default" size="100%">Spector, Stephen A.</style></author><author><style face="normal" font="default" size="100%">Richman, Douglas D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Randomized Trial of the Activity and Safety of Ro 24-7429 (Tat Antagonist) versus Nucleoside for Human Immunodeficiency Virus Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Infectious Diseases</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">1995</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 1, 1995</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://jid.oxfordjournals.org/content/172/5/1246.abstract</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">172</style></volume><pages><style face="normal" font="default" size="100%">1246-1252</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Ro 24-7429, a Tat antagonist, dosed at 75, 150, or 300 mg/day, was compared with nucleoside analogue (zidovudine or didanosine) for 12 weeks in 96 human immunodeficiency virus (HIV)-infected patients to assess safety and activity. The primary adverse effect of Ro 24-7429 was rash, which necessitated treatment discontinuation in 6 of 71 patients. Nucleoside analogue treatment produced an average increase in CD4 cell count of 28 cells/mm3 at week 8 versus a decrease of 27 cells/mm3 in recipients of Ro 24-7429 (P &lt; .001). Serum HIV p24 antigen levels decreased by an average of 111 pg/mL in nucleoside recipients at week 8 compared with an increase of 41 pg/mL in recipients of Ro 24-7429 (P = .007). Nucleoside-treated patients had a mean 0.66 log10 reduction in infectious peripheral blood mononuclear cells, while Ro 24-7429 recipients had a mean 0.02 log10 reduction (P = .02). No dose-response relationships were observed in the Ro 24-7429 groups. In this study, Ro 24-7429 treatment showed no evidence of antiviral activity.</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue></record></records></xml>