Citation:
Karaflou M, Kaparos G, Rizos D, Creatsa M, Christodoulakos G, Lambrinoudaki I. Estrogen plus progestin treatment: Effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women. Fertility and Sterility. 2010;94(6):2399 - 2401.
Abstract:
One hundred healthy postmenopausal women were randomly assigned to receive 17β-E2 1 mg/drospirenone 2 mg or 17β-E2 1 mg/norethisterone acetate 0.5 mg for 6 months, and circulating soluble Fas, soluble Fas ligand, and cytochrome c were measured at baseline and at 6 months in 87 women who completed the study. Although cytochrome c levels were undetectable, circulating soluble Fas/soluble Fas ligand ratio decreased in both groups, suggesting a decrease in ligand-mediated apoptosis. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.
