Publications

2021
Kandaraki A, Vousoura E, Argyropoulos S, Ginieri-Coccossis M, Papadimitriou GN, Papageorgiou C, Zervas IM. {Psychological Differences Between Greek Artists With and Without History of Major Psychopathology}. Journal of Creativity in Mental Health [Internet]. 2021;16:168–181. Website
Vousoura E, Ekizoglou C. {Does Bed Sharing with an Infant Influence Parents' Sexual Life? A Scoping Review in Western Countries}. Sexes [Internet]. 2021;2:406–414. WebsiteAbstract
Bed sharing—the sharing of a sleeping surface by parents and children—is a common, yet controversial, practice. While most research has focused on the public health aspect of this practice, much less is known regarding its effect on the marital relationship. The aim of the present study was to conduct a scoping review on the impact of parent–infant bed sharing sleeping practices on the sexual and marital relationship of couples. The qualitative synthesis of six studies on this topic suggests that overall, bed sharing does not exert a significant negative impact on family functioning; when it does, it appears to be related to incongruent parental beliefs and expectations, especially when bed sharing is not an intentional choice of sleep arrangement, and there are other confounding factors such as fatigue and psychological distress. Suggestions for future studies and clinical implications are discussed.
Vousoura E, Gergov V, Tulbure BT, Camilleri N, Saliba A, Garcia-Lopez LJ, Podina IR, Prevendar T, Löffler-Stastka H, Chiarenza GA, et al. {Predictors and moderators of outcome of psychotherapeutic interventions for mental disorders in adolescents and young adults: protocol for systematic reviews}. Systematic Reviews [Internet]. 2021;10:239. Website
Konstantakou P, Chalarakis N, Valsamakis G, Sakkas EG, Vousoura E, Gryparis A, Sakkas GE, Papadimitriou G, Zervas I, Mastorakos G. {Associations of Thyroid Hormones Profile During Normal Pregnancy and Postpartum With Anxiety, Depression, and Obsessive/Compulsive Disorder Scores in Euthyroid Women}. Frontiers in Neuroscience [Internet]. 2021;15:239. Website
Branquinho M, de la Rodriguez-Muñoz MF, Maia BR, Marques M, Matos M, Osma J, Moreno-Peral P, Conejo-Cerón S, Fonseca A, Vousoura E. {Effectiveness of psychological interventions in the treatment of perinatal depression: A systematic review of systematic reviews and meta-analyses}. Journal of Affective Disorders [Internet]. 2021;291:294–306. Website
2019
Zoogman S, Goldberg SB, Vousoura E, Diamond MC, Miller L. {Effect of Yoga-Based Interventions for Anxiety Symptoms: A Meta-Analysis of Randomized Controlled Trials}. Spirituality in Clinical Practice. 2019.Abstract
© 2019 American Psychological Association. Anxiety is a common and debilitating condition, which tends to follow a chronic course if left untreated. While studies have provided evidence that yoga is an effective mind-body intervention for a variety of psychological symptoms, more meta-analytic evidence supporting yoga's efficacy specifically for anxiety symptoms is needed. The aim of this study was to investigate the effect of yoga on anxiety symptoms using meta-analytic methods. A systematic search was conducted for randomized controlled trials (RCTs) on yoga and anxiety on electronic databases over key terms. Risk of bias was assessed using the Cochrane tool. Outcome data were extracted from eligible studies, and moderators were coded across studies to indicate differences in study sample, delivery method, and type of dependent variable. Effect size aggregation and omnibus analyses, as well as moderator tests, were performed. A total of 38 RCTs (N = 2,295 adults) met inclusion criteria. Yoga practice had a large and statistically significant effect on anxiety symptoms compared with control conditions (d = 0.80). In subomnibus analyses, statistically significant effects of the yoga intervention were detected on biological measures (d = 0.45), nonanxiety mental health outcomes (d = 0.55), physical health measures (d = 0.45), and mental and physical health outcomes combined (d = 0.65). Significant moderation was found by study location, with the largest effects appearing in Indian samples. Results suggest that yoga significantly decreases anxiety symptoms, while it appears to have an ameliorative effect on psychological symptoms more globally.
2018
Alevizou F, Vousoura E, Leonardou A. {Premenstrual dysphoric disorder: A critical review of its phenomenology, etiology, treatment and clinical status}. Current Women's Health Reviews. 2018;14.Abstract
© 2018 Bentham Science Publishers. Background: Premenstrual Dysphoric Disorder (PMDD) is a newly recognized diagnostic entity in the DSM-5, characterized by intense mood and cognitive fluctuations accompanied by distressing physical symptoms. PMDD symptoms typically arise after ovulation and gradually resolve after the onset of menstruation. With an estimated prevalence of 3-8% in the general female population, PMDD is a chronic and impairing disorder that affects significantly women's quality of life and everyday functioning. Objective: The aim of this article is to review the existing literature on biological, genetic and psychological etiological factors in PMDD and to discuss corresponding treatment considerations. Results: Fluctuations in the functions of sex hormones, serotonin and GABA neurotransmitters, as well as personality traits related to stress and vulnerability to negative effect are implicated in the development of PMDD. Available evidence-based treatments include a number of hormonal therapies and antidepressant medications, while there is accumulating evidence for the clinical utility of psychotherapeutic interventions. Controversies in the diagnostic validity of PMDD mainly concern the asserted social constructiveness of the disorder and the difficulty to validly distinguish PMDD from other mood disorders with similar symptomatology. Conclusion: Controversies pertaining to the clinical nature and taxonomy of PMDD are highlighted and recommendations are offered, focusing on the need to identify biomarkers for PMDD and to investigate possible efficacy of non-pharmacological, psychotherapeutic interventions to address PMDD.
2017
Varela P, Spyropoulou AC, Kalogerakis Z, Vousoura E, Moraitou M, Zervas IM. {Association between gestational diabetes and perinatal depressive symptoms: Evidence from a Greek cohort study}. Primary Health Care Research and Development. 2017;18.Abstract
© Cambridge University Press 2017. Aim: The aim of the present study was to assess the association of gestational diabetes mellitus (GDM) with prenatal and postnatal depressive symptoms in a sample of pregnant women in Greece. Background: Earlier research supports a relationship between depression and diabetes, but only a few studies have examined the relationship between GDM and perinatal depressive symptomatology. Methods: A total of 117 women in their third trimester of pregnancy participated in the study. Demographic and obstetric history data were recorded during women's third trimester of pregnancy. Depressive symptoms were assessed with the validated Greek version of the Edinburg Postnatal Depression Scale (EPDS) at two time points: on the third trimester of pregnancy and on the first week postpartum. Findings: Prevalence of GDM was 14.5%. Probable diagnosis of depression occurred for 12% of the sample during the antenatal assessment and 15.1% in the postpartum assessment. In the first week postpartum, women with GDM had significantly higher postpartum (but no antenatal) EPDS scores compared with the non-GDM cohort. In conclusion, GDM appears to be associated with depressive symptoms in the first week postpartum. Clinical implications and recommendations for future research are discussed, emphasizing the importance of closely monitoring women with GDM who seem more vulnerable to developing depressive symptomatology during the postnatal period.
Bacopoulou F, Foskolos E, Stefanaki C, Tsitsami E, Vousoura E. {Disordered eating attitudes and emotional/behavioral adjustment in Greek adolescents}. Eating and Weight Disorders. 2017.Abstract
{© 2017 Springer International Publishing AG, part of Springer Nature Purpose: The aim of this study was to examine the relationship between disordered eating attitudes and emotional/behavioral adjustment in Greek adolescents as well as the moderating role of gender and body mass index (BMI) in this relationship. Methods: Ninety adolescents, 11–18 years old, were assessed using anthropometric measurements; demographics, eating attitudes and level of emotional/behavioral adjustment were examined via self-reported questionnaires. Results: Disordered eating attitudes were prevalent in 17.8% of the sample. A significant relationship was found between disordered eating attitudes and Youth Self-Report (YSR) anxiety score (r = .22, p < .05). Gender significantly moderated the relationship between YSR anxiety symptoms and Eating Attitudes Test (EAT) scores (b = .59
2016
Karamanolaki H, Spyropoulou AC, Iliadou A, Vousoura E, Vondikaki S, Pantazis N, Vaslamatzis G. {Birth order and memories of traumatic and family experiences in Greek patients with borderline personality disorder versus patients with other personality disorders}. Bulletin of the Menninger Clinic. 2016;80.Abstract
© 2016 The Menninger Foundation. The purpose of this study was to assess the possible effect of recalled traumatic experiences, perceived parental rearing styles, and family parameters on the occurrence of borderline personality disorder (BPD) versus other personality disorders (other-PDs). A total of 88 adult outpatients with personality disorders completed the Traumatic Antecedents Questionnaire and the Egna Minnen av Barndoms Uppfostran, which measures perceptions regarding parental rearing. Results indicated that incidence of traumatic childhood experiences was higher among those in the BPD group compared to those in the other-PD group. Firstborns were less likely to carry a diagnosis of BPD over other-PDs. Also, significantly more BPD compared to other-PD patients reported being the father's favorite child over siblings. Results suggest that traumatic exper iences, birth order, and family interactions in the presence of siblings seem to differentially affect the formation of borderline diagnosis compared to other-PDs. Limitations and clinical implications of the study are discussed in detail.
Gomes MF, Chowdhary N, Vousoura E, Verdeli H. {“When Grief Breaks Your Heart”: A Case Study of Interpersonal Psychotherapy Delivered in a Primary Care Setting}. Journal of Clinical Psychology. 2016;72.Abstract
© 2016 Wiley Periodicals, Inc. Depression and anxiety, the so-called common mental disorders (CMDs), are highly prevalent and disabling, yet remain largely untreated. This treatment gap is particularly true in low- and middle-income settings, where there is significant scarcity of resources (including human resources) and treatment accessibility is complicated by stigma surrounding mental illness. To address these challenges, the MANAS trial, one of the largest to date randomized, controlled trials, aimed to test the effectiveness of a stepped care intervention led by lay health counselors in primary care settings in Goa, India. Six- and 12-month follow-up outcomes suggest that MANAS was a safe, feasible, effective, and cost-effective intervention for CMDs in that context. This article demonstrates the use of culturally adapted IPT as an intervention to treat CMDs in a 54-year-old Indian primary care patient struggling with depression and heart-related problems after his wife's death. A case formulation is presented based on core IPT principles, followed by detailed delineation of treatment from beginning through termination.
2015
Teel KSKS, Verdeli H, Wickramaratne P, Warner V, Vousoura E, Haroz EEE, Talati A. {Impact of a Father Figure's Presence in the Household on Children's Psychiatric Diagnoses and Functioning in Families at High Risk for Depression}. Journal of Child and Family Studies [Internet]. 2015;25:1–10. WebsiteAbstract
© 2015, Springer Science+Business Media New York. The consequences of living in single-parent households on children's wellbeing are well documented, but less is known about the impact of living in single-mother households among children with high familial risk for depression. Utilizing data from an ongoing three-generation study of high-risk families, this preliminary study examined a sample of 161 grandchildren of probands diagnosed with major depressive disorder, comparing those in single-parent households to those in dual-parent households with household status defined as the full-time presence of a resident male in the home. High-risk children were compared across households in terms of psychiatric diagnoses (measured by Schedule for Affective Disorders and Schizophrenia for School-Age Children; K-SADS-PL) and global functioning (assessed by Global Assessment Scale, child version; C-GAS). Results indicated that high-risk children in single-parent households had 4.7 times greater odds for developing a mood disorder and had significantly lower mean C-GAS scores (p = 0.01) compared to those in dual-parent households. Differences remained significant when controlling for household income, child's age, and either parent's depression status. There were no significant differences between high-risk children across households when household status was instead defined as legal marital status. This study has several limitations: sample size was small, probands were recruited from a clinical population, and participants had not passed completely through the period of risk for adult psychiatric disorders. These findings point towards the importance of identifying and closely monitoring children at risk for depression, particularly if they reside in households without a resident father figure.
Mourikis I, Antoniou M, Matsouka E, Vousoura E, Tzavara C, Ekizoglou C, Papadimitriou GN, Vaidakis N, Zervas IM. {Anxiety and depression among Greek men with primary erectile dysfunction and premature ejaculation}. Annals of General Psychiatry [Internet]. 2015;14:34. Website
2014
Vousoura E, Verdeli H. {Psychological distress among mothers of young children in rural Ghana and Uganda and its association}. Columbia University Academic Commons [Internet]. 2014. WebsiteAbstract
Depression and anxiety, the most common mental disorders (CMD), are highly prevalent among women of childbearing age, but are even higher among mothers in low- and middle-income countries (LMIC), possibly due to mothers' disproportionate exposure to multiple risk factors, such as poverty, gender disparities and violence, and a high prevalence of medical illness. The extra burden imposed by maternal CMD in LMIC can be nothing short of catastrophic, affecting infant and child growth and leading to preventable illness and death among children. One possible mechanism, by which maternal CMD lead to compromised child development, is through negatively affecting mothers' health-promoting behaviors (e.g., contraceptive use, participation in antenatal care) and child-care practices (e.g., vaccination uptake, cessation of breastfeeding, sanitation practices). The aim of this study was three-fold. First, to assess psychological distress among mothers of young children (aged 0-5 years) as measured by the Kessler 6 (K6), a brief screening instrument for nonspecific psychological distress in Ghana and Uganda. Second, to identify sociodemographic, socioeconomic, obstetric, and psychosocial correlates of maternal psychological distress in Ghana and Uganda. Third, to explore the relationship between maternal psychological distress, child health-promoting practices, and child health outcomes and nutritional status. The study utilized cross-sectional baseline data from the Millennium Villages Project. One hundred mothers in Ghana and 100 in Uganda who had at least one child up to 5 years at the time of baseline collection participated in the study. Results provided evidence for the adequate reliability and validity of the K6 in our study. Several correlates of maternal distress were identified in the study, some of which were common for both sites, while others where site-specific. Maternal distress was associated with maternal sanitation practices in Uganda. An exploratory analysis revealed a significant relationship between maternal distress and risk for child undernutrition. These findings offer partial support for the relationship between maternal psychological distress and poor child health outcomes. Discussion of the study findings focuses on the social roots of maternal distress in SSA. The clinical implications of the study and recommendations for future research are discussed.
2012
Vousoura E, Verdeli H, Warner V, Wickramaratne P, Baily CDR. {Parental Divorce, Familial Risk for Depression, and Psychopathology in Offspring: A Three-Generation Study}. Journal of Child and Family Studies [Internet]. 2012;21:718–725. WebsiteAbstract
Research suggests a link between parental divorce and negative child outcomes; however, the presence of parental depression may confound this relationship. Studies exploring the simultaneous effects of depression and parents' divorce on the adjustment of their children are scarce and rarely have a longitudinal design. This is the first three-generation study of the relative effects of depression and divorce on offspring psychopathology, based on data from a 25-year longitudinal study with families at high and low risk for depression. One hundred seventy-eight grandchildren (mean age = 13.9 years) of depressed and nondepressed parents and grandparents were evaluated by raters blind to their parents' and grandparents' clinical status. We found that in both low and high-risk children, divorce had a limited impact on child adjustment over and above familial risk for depression. Divorce had a significant effect on child outcomes only among high-risk grandchildren with a depressed grandparent and nondepressed parents, with this group showing a threefold risk for anxiety disorders. Results support previous findings suggesting that familial risk for depression largely overshadows the effect of parental divorce on child psychopathology. Possible reasons for the lack of association between divorce and child psychopathology among low-risk offspring are discussed. (PsycINFO Database Record (c) 2012 APA, all rights reserved) (journal abstract)
Mitsonis C, Voussoura E, Dimopoulos N, Psarra V, Kararizou E, Latzouraki E, Zervas I, Katsanou MNM-N. {Factors associated with caregiver psychological distress in chronic schizophrenia}. Social Psychiatry and Psychiatric Epidemiology [Internet]. 2012;47:331–337. WebsiteAbstract
BACKGROUND AND AIMS: Caregivers of patients with schizophrenia experience increased levels of psychological distress. This study investigated the impact of caring for patients with chronic schizophrenia on the mental health status of the caregivers and described the relationship between various socio-demographic and clinical characteristics and caregiving psychological distress.\n\nMETHODS: The study was carried out at the Psychiatric Hospital of Athens. The Symptom Check List Revised (SCL-90-R) was administered to 87 caregivers of chronic schizophrenia patients and 90 healthy controls. The Positive and Negative Syndrome Scale (PANSS) was administered to schizophrenia patients in order to assess illness severity.\n\nRESULTS: The group of caregivers scored higher on the majority of symptom dimensions of the SCL-90-R than the control group. Clinical features of schizophrenia, i.e. duration of illness and PANSS positive and negative symptoms significantly predicted caregiving psychological distress. Caregivers' and patients' socio-demographic characteristics were not associated with caregivers' distress, with the exception of caregivers' sex: female caregivers experienced significantly higher levels of psychological distress than males.\n\nCONCLUSIONS: The study suggests that clinical features of schizophrenia influence distress levels in caregivers of patients with chronic schizophrenia. The stronger predictors of distress appear to be female caregiver's gender, duration of illness as well as positive and negative symptomatology.
2011
a. Keith J, Verdeli H, Vousoura E. {Evaluating the Clinical Significance of Depression Treatment}. International Journal of Mental Health [Internet]. 2011;40:3–28. Website
Verdeli H, Baily C, Vousoura E, Belser A, Singla D, Manos G. {The case for treating depression in military spouses.}. Journal of Family Psychology [Internet]. 2011;25:488–496. WebsiteAbstract
The increased operational tempo associated with current deployments to Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) is placing considerable strain on military families. Among other sequelae of OIF and OEF deployment, findings from recent studies suggest high rates of depression in spouses of service members. This review presents a rationale for targeting depression among military spouses. It examines how stressors relating to the deployment cycle may contribute to depression in spouses and outlines the effects of spousal depression on the mental health of service members and their children. Mental health services currently available to military spouses as well as barriers to their care are also described. Considerations for the adaptation of treatment to their unique circumstances and needs are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved).
Mitsonis C, Dimopoulos N, Zavrou M, Psarra V, Giofkos C, Fiorakis C, Dimitriadis A, Valavanis D, Vousoura E, Zervas I, et al. {Panic attack during elective gastrointestinal endoscopy}. Gastroenterology Research and Practice [Internet]. 2011;2011:162574. WebsiteAbstract
Background. Esophagogastroduodenoscopy (EGD) and colonoscopy (CS) can evoke anxiety, embarrassment, and discomfort. These concerns can culminate in panic attacks, which may traumatize patients and significantly decrease their compliance to the procedure. The objective of this study was to evaluate the relationship between preendoscopic anxiety and the possibility of a panic attack during an elective gastrointestinal endoscopy (EGE). Methods. The study population comprised of 79 Greek outpatients. The examination was carried out without the use of conscious sedation. Patients' anxiety levels were assessed before the procedure using the Greek version of the Spielberger State-Trait Anxiety Inventory (STAI-Y). Results. Seventy-nine patients were enrolled: 45 EGD and 34 CS. Females had higher state and trait anxiety levels than males (48.14 ± 7.94 versus 44.17 ± 7.43, P < 0.05; and 43.68 ± 6.95 versus 39.86 ± 7.46, P < 0.05). Patients who experienced panic attack had significantly higher levels of both trait and state anxiety, compared to those who were panic-free. There was no significant relationship between panic attacks and sex or type of procedure. Conclusions. Patients who experience panic attacks during endoscopic procedures appear to have significantly higher anxiety levels before the procedure. Administering the STAI questionnaire prior to the endoscopy seems to be a useful screening method for vulnerable patients.
2010
Vousoura E. {Onset or Exacerbation of OCD During Pregnancy: Clinical Characteristics and Etiological Considerations}. Graduate Student Journal of Psychology [Internet]. 2010:37–44. Website
2009
Zervas IIMM, Lambrinoudaki I, Spyropoulou ACAC, Koundi KL, Voussoura E, Tzavara C, Verdeli H, Aravantinos L, Creatsa M, Paparrigopoulos T. {Additive effect of depressed mood and vasomotor symptoms on postmenopausal insomnia.}. Menopause (New York, N.Y.) [Internet]. 2009;16:837–842. WebsiteAbstract
OBJECTIVE: The aim of this study was to investigate the role of vasomotor and mood symptoms on insomnia in postmenopausal women. METHODS: One hundred sixty-three postmenopausal women, not receiving hormone therapy, attending a menopause clinic at the University of Athens, Greece, were included in this cross-sectional study. Climacteric symptoms were assessed by Greene's scale, whereas psychological morbidity was measured by Zung Self-Assessment Depression Scale, Symptom Checklist-90-R, and Athens Insomnia Scale. RESULTS: Vasomotor symptoms were significantly associated with insomnia (P = 0.001). When depressive symptomatology was added to the logistic regression analysis, the predictive ability of the model was significantly improved as defined by the increase in the log likelihood (P < 0.001) and the increase in the area under the receiver operating characteristic curve. CONCLUSIONS: Insomnia in postmenopausal women attending a menopause clinic is related both to the effects of vasomotor symptoms and depressive symptomatology. Mood symptoms seem to affect sleep independently of vasomotor symptoms, suggesting that depression should be carefully assessed and treated in postmenopausal women with insomnia.
Zervas IM, Lambrinoudaki I, Spyropoulou AC, Koundi KL, Voussoura E, Tzavara C, Verdeli H, Aravantinos L, Creatsa M, Paparrigopoulos T. {Additive effect of depressed mood and vasomotor symptoms on postmenopausal insomnia}. Menopause. 2009;16:837–842.Abstract
OBJECTIVE: The aim of this study was to investigate the role of vasomotor and mood symptoms on insomnia in postmenopausal women. METHODS: One hundred sixty-three postmenopausal women, not receiving hormone therapy, attending a menopause clinic at the University of Athens, Greece, were included in this cross-sectional study. Climacteric symptoms were assessed by Greene's scale, whereas psychological morbidity was measured by Zung Self-Assessment Depression Scale, Symptom Checklist-90-R, and Athens Insomnia Scale. RESULTS: Vasomotor symptoms were significantly associated with insomnia (P = 0.001). When depressive symptomatology was added to the logistic regression analysis, the predictive ability of the model was significantly improved as defined by the increase in the log likelihood (P < 0.001) and the increase in the area under the receiver operating characteristic curve. CONCLUSIONS: Insomnia in postmenopausal women attending a menopause clinic is related both to the effects of vasomotor symptoms and depressive symptomatology. Mood symptoms seem to affect sleep independently of vasomotor symptoms, suggesting that depression should be carefully assessed and treated in postmenopausal women with insomnia. © 2009 The North American Menopause Society.