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Seroprevalence of diphtheria, tetanus and pertussis antibodies and Tdap vaccination in pregnant women in Greece - A cross- sectional study

Citation:

Papailiou S, Soldatou A, Marmarinos A, Avgeris M, Papathoma E, Sindos M, Georgantzi S, Rodolakis A, Iacovidou N, Gourgiotis D, Tsolia M. Seroprevalence of diphtheria, tetanus and pertussis antibodies and Tdap vaccination in pregnant women in Greece - A cross- sectional study. Vaccine 2024;42:126435.

Abstract:

OBJECTIVES: We performed a cross- sectional study in two maternity hospitals in Athens, Greece between 2017 and 2019 assessing seroprevalence and Geometric Mean Titres (GMTs) of diphtheria, pertussis and tetanus antibodies in pregnant women and recorded adherence to Greek National Immunization Program (NIP) regarding Tdap vaccination in pregnancy. METHODS: Blood samples were collected from women in labour and anti- diphtheria, tetanus and pertussis toxin IgG antibodies were measured by Elisa kits. Seropositivity was defined as anti-diphtheria and anti- tetanus toxin IgG levels >/=0.1, and anti- pertussis >50 IU/mL. Seroprevalence and GMTs were calculated according to demographic factors. Tdap vaccination before and during pregnancy was self-reported by study participants. RESULTS: We analysed 253 blood samples and paired questionnaires. Seropositivity was 57.7 % for diphtheria. The lowest rate (38.2 %) was observed in the youngest age group (

Notes:

Papailiou, SSoldatou, AMarmarinos, AAvgeris, MPapathoma, ESindos, MGeorgantzi, SRodolakis, AlphaIacovidou, NGourgiotis, DTsolia, MengResearch Support, Non-U.S. Gov'tNetherlands2024/10/23 04:22Vaccine. 2024 Dec 2;42(26):126435. doi: 10.1016/j.vaccine.2024.126435. Epub 2024 Oct 21.