Abstract:

Waldenström's Macroglobulinemia (WM) is a neoplastic B lymphoid disorder characterized by the bone marrow (BM) infiltration by a lymphoplasmatic clone that produces a monoclonal immunoglobulin (Ig) of the IgM type. WM is named after Jan Waldenström, a Swedish physician who first described two patients who presented with oronasal bleeding, lymphadenopathy, anemia and thrombocytopenia, elevated erythrocyte sedimentation rate, high serum viscosity, normal bone radiographs, and BM infiltration by lymphoid cells. At that time serum electrophoresis was not available and he attributed the hyperviscosity to an abnormal high-molecular-weight serum protein, which subsequently was shown to be a monoclonal IgM. These two first patients presented with several of the most common features of WM, as have been subsequently described [1]. © 2012 Springer-Verlag London. All rights are reserved.

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Export Date: 21 February 2017

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