Abstract:

We have studied drug release from matrices with periodic layers of high and low diffusivity using Monte Carlo simulations. Despite the fact, that the differential equations relevant to this process have a form that is quite different from the classical diffusion equation with constant diffusion coefficient, we have found that the Weibull model continues to describe the release process as well as in the case of the ``classical{''} diffusion controlled drug release. We examine the similarities and differences between release from matrices with periodic layers and matrices with random mixtures of high and low diffusivity area and show that the periodic geometrical arrangement of the low diffusivity areas has an influence in the release profile which is negligible for low diffusivity ratios, but becomes important in the case of high diffusivity ratios and for intermediate values of the periodic ``length{''}. Such an arrangement in periodic layers leads to Weibull exponent a which are lower than those of the corresponding random arrangement and exponents b which are higher than those of the random case. (C) 2007 Elsevier B.V. All rights reserved.