HOME / PUBLICATIONS /

First trimester maternal plasma proteomic changes predictive of spontaneous moderate/late preterm delivery

Citation:

Mavreli D, Theodora M, Lambrou G, Avgeris M, Papantoniou N, Treager-Synodinos J, Daskalakis G, Kolialexi A. First trimester maternal plasma proteomic changes predictive of spontaneous moderate/late preterm delivery. J Matern Fetal Neonatal Med 2023;36:2232074.

Abstract:

OBJECTIVE: Identification of differentially expressed proteins (DEPs) in first trimester maternal plasma between pregnant women with a subsequent spontaneous moderate/late Preterm Delivery (sPTD) and women who delivered at term. The sPTD group consisted of women who delivered between 32 degrees (/7) and 36(6/7 )weeks of gestation. METHODS: Isobaric tags for relative and absolute quantification (iTRAQ) coupled with LC-MS/MS was used for the analysis of five first trimester maternal plasma samples obtained from women with a subsequent moderate/late preterm sPTD and five women with term deliveries. Enzyme-linked immunosorbent assay (ELISA) was further applied in an independent cohort of 29 sPTD cases and 29 controls to verify the expression levels of selected proteins. RESULTS: 236 DEPs, mainly linked to coagulation and complement cascade, were identified in first trimester maternal plasma obtained from the sPTD group. Decreased levels of selected proteins, namely, VCAM-1, SAA, and Talin-1, were further confirmed using ELISA, highlighting their potential as candidate predictive biomarkers for sPTD at32 degrees (/7) and 36(6/7 )weeks of gestation. CONCLUSION: First trimester maternal plasma proteomic analysis revealed protein changes associated with subsequent moderate/late preterm sPTD.

Notes:

Mavreli, DanaiTheodora, MarianaLambrou, GeorgeAvgeris, MargaritisPapantoniou, NikolasTreager-Synodinos, JanDaskalakis, GeorgeKolialexi, AggelikiengEngland2023/07/10 06:42J Matern Fetal Neonatal Med. 2023 Dec;36(2):2232074. doi: 10.1080/14767058.2023.2232074.