MMP-2 -1306C > T polymorphism in breast cancer: A case-control study in a South European population

Citation:

Zagouri F, Sergentanis TN, Gazouli M, Dimitrakakis C, Tsigginou A, Papaspyrou I, Chrysikos D, Lymperi M, Zografos GC, Antsaklis A, et al. MMP-2 -1306C > T polymorphism in breast cancer: A case-control study in a South European population. Molecular Biology Reports [Internet]. 2013;40(8):5035 - 5040.

Abstract:

This case control study aims to investigate the role of MMP-2 -1306C > T polymorphism as a potential risk factor and possible prognostic marker for breast cancer in a South European population. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy controls were recruited. MMP-2 -1306C > T polymorphism was genotyped; multivariate logistic regression as well as Cox regression analysis were performed. MMP-2 -1306C > T status was not associated with breast cancer risk either at the total sample or at the subanalyses on premenopausal and postmenopausal women. At the survival analysis, a trend towards a favorable association between MMP-2 -1306C > T allele and disease-free survival as well as overall survival was observed. Regarding subanalyses on ER-negative and ER-positive cases, the favorable association implicating MMP-2 -1306C > T allele was particularly evident among ER-positive cases; no significant associations emerged among ER-negative cases. MMP-2 -1306C > T polymorphism does not seem to be a risk factor for breast cancer in South European population; however, a trend towards a favorable association with survival has been observed. © 2013 Springer Science+Business Media Dordrecht.

Notes:

Cited By :2Export Date: 21 February 2017

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