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A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function

Citation:

Minadakis M-P, Mavreas KF, Neofytos DD, Paschou M, Kogkaki A, Athanasiou V, Mamais M, Veclani D, Iatrou H, Venturini A, et al. A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function. Organic & Biomolecular Chemistry [Internet]. 2022;20(12):2407 - 2423.

Abstract:

Synthesis and study of RotA, an inhibitor of glycogen phosphorylase (GP), which when bound at the active site of GP, produces a strong fluorescence signal, allowing utilization of RotA as a probe that brings GP “to light” in the cellular milieu.

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