We present a systematic method for constructing two-dimensional magnetohydrodynamic equilibria with compressible flow in Cartesian geometry. This systematic method has already been developed in spherical geometry and applied in modelling solar and stellar winds and outflows (Vlahakis & Tsinganos \cite{Vlahakis98}) but is derived here in Cartesian geometry in the context of the solar atmosphere for the first time. Using the method we find several new classes of solutions, some of which generalise known solutions, including the Kippenhahn & Schlüter (\cite{Kippenhahn57}) and Hood & Anzer (\cite{Hood90}) solar prominence models and the Tsinganos et al. (\cite{Tsinganos93}) coronal loop model with flow, and some of which are completely new. Having developed the method in full and summarised the several classes of solutions, we explore in a some detail one of the classes to illustrate the general construction method. From one of the new classes of solutions we calculate two loop-like solutions, one of which is the first exact two-dimensional magnetohydrodynamic equilibrium with trans-Alfvénic flow.